Innate Immune System Activation, Inflammation and Corneal Wound Healing
Abstract
:1. Introduction—The Cornea
2. Corneal Wound Healing
2.1. The Healing Process
2.2. Importance of the Limbal Stem Cell Population and Certain Signaling Pathways
2.3. Importance of the Innate Immune System and Cytokines in Wound Healing and Corneal Inflammation
2.3.1. Role of IL-1 in Wound Healing and Corneal Inflammation
2.3.2. Role of TNF-α and IL-6 in Corneal Inflammation
3. Injury-Induced Corneal Inflammation and Its Role in Wound Healing
3.1. Infectious Corneal Inflammation (Nonsterile)
3.1.1. Bacterial Infection
Pseudomonas aeruginosa
Staphylococcus aureus
3.1.2. Fungal Infection
Aspergillus
Fusarium
3.2. Sterile Corneal Inflammation (Non-Infectious)
4. Diabetes and Corneal Wound Healing
5. Anti-Inflammatory Actions of Phosphatidylglycerol
6. Phosphatidylglycerol as a Potential Therapeutic Treatment
7. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Fortingo, N.; Melnyk, S.; Sutton, S.H.; Watsky, M.A.; Bollag, W.B. Innate Immune System Activation, Inflammation and Corneal Wound Healing. Int. J. Mol. Sci. 2022, 23, 14933. https://doi.org/10.3390/ijms232314933
Fortingo N, Melnyk S, Sutton SH, Watsky MA, Bollag WB. Innate Immune System Activation, Inflammation and Corneal Wound Healing. International Journal of Molecular Sciences. 2022; 23(23):14933. https://doi.org/10.3390/ijms232314933
Chicago/Turabian StyleFortingo, Nyemkuna, Samuel Melnyk, Sarah H. Sutton, Mitchell A. Watsky, and Wendy B. Bollag. 2022. "Innate Immune System Activation, Inflammation and Corneal Wound Healing" International Journal of Molecular Sciences 23, no. 23: 14933. https://doi.org/10.3390/ijms232314933