Circulating Levels of Ferritin, RDW, PTLs as Predictive Biomarkers of Postoperative Atrial Fibrillation Risk after Cardiac Surgery in Extracorporeal Circulation
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population and Design
2.2. Postoperative Monitoring
2.3. Electrocardiographic and Echocardiographic Parameters in the Groups 0 and 1
2.4. Laboratory Analysis
2.5. Statistical Analysis
3. Results
3.1. Demographic and Basal Clinical Characteristics of Patients Enrolled in the Study
3.2. Evaluation of Circulating Ferritin Levels and Other Haemato-Chemical Biomarkers in POAF vs. No POAF Cases
3.3. Cut-Off Values of Mean Serun Ferritin Levels for Predicting the Occurrence of POAF in the 105 Patients Enrolled
3.4. Major Prevalence of Risk POAF Factors in the Group 1 vs. Group 0
3.5. Significant Correlation between PWd, P-min, and P-max with Mean Serum Ferritin Levels and the Percentage of RDW in the Case Group 1 vs. Group 0
3.6. The Association of PW Indices with Structural Heart Disease Variables in the Group 1 after Surgery
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Variables | Overall | Without POAF | With POAF | p-Value |
---|---|---|---|---|
N = 105 | N = 70 (67.0) | N = 35 (33.0) | ||
Gender, n (%), n (%): | ||||
F | 35 (33.0) | 21 (30.0) | 11 (31.0) | 0.79 † |
M | 70 (67.0) | 49 (70.0) | 24 (69.0) | |
Age (mean ± SD) | 70.1 ± 7.1 | 67 ± 6.8 | 73.3 ± 7.6 | 0.005 ^ |
Body surface area (BSA), (mean ± SD) | 1.81 ± 4.8 | 1.82 ± 4.6 | 1.92 ± 4.8 | 0.44 ^ |
HYPERTENSION, n (%), n (%): | 0.06 § | |||
No | 18 (17.0) | 21(30.0) | 3 (9.6) | |
YES | 87 (83.0) | 49 (70.0) | 32 (91.4) | |
Smoking, n (%): | 0.84 † | |||
Ex | 22 (21.0) | 14 (20.0) | 8 (23.0) | |
No | 27 (26.0) | 18 (26.0) | 9 (26.0) | |
YES | 56 (53.0) | 38 (54.0) | 18 (51.0) | |
DIABETES, n (%): | 0.45 § | |||
No | 82 (78.0) | 55 (78.0) | 27 (77.0) | |
YES | 23 (22.0) | 15 (22.0) | 8 (23.0) | |
DYSLIPIDEMIA, n (%): | 0.12 § | |||
No | 73 (69.0) | 50 (71.0) | 23 (66.0) | |
YES | 32 (31.0) | 20 (29.0) | 12 (34.0) | |
Chronic obstructive pulmonary disease (COPD), n (%): | 0.001 § | |||
No | 80 (78.0) | 63 (90.0) | 17 (48.5) | |
YES | 25 (22.0) | 7 (10.0) | 18 (51.5) | |
OBESITY, n (%): | 0.003 § | |||
No | 73 (70.0) | 58 (83.0) | 15 (43.0) | |
YES | 32 (30.0) | 12 (17.0) | 20 (57.0) | |
Previous cardiovascular diseases (CVD), n (%): | 0.003 § | |||
No | 73 (70.0) | 56 (80.0) | 17 (48.5) | |
YES | 32 (30.0) | 14 (20.0) | 18 (51.5) | |
Amiodarone., n (%): | 0.29 § | |||
No | 87 (83.0) | 61 (87.0) | 26 (74.0) | |
YES | 18 (17.0) | 9 (13.0) | 9 (26.0) | |
ACE-INHIBITORS., n (%): | 0.497 † | |||
No | 73 (70.0) | 45 (64.0) | 28 (80.0) | |
YES | 32 (30.0) | 25 (36.0) | 7 (20.0) |
Variables | Overall | Without POAF | With POAF | p-Value ^ (POAF Cases vs. Cases without POAF) |
---|---|---|---|---|
N = 105 | N = 70 | N = 35 | ||
Hemoglobin, HB (g/dL) (mean ± SD) | 13.1 ± 4.2 | 12.8 ± 5.6 | 10.4 ± 3.6 | 0.024 |
PLT 103/µL | 227.3 ± 1058 | 230 ± 5.7 | 251 ± 5.6 | <0.0001 |
CREATININE (mg/dL) | 1.30 ± 7.2 | 0.97 ± 7.2 | 1.48 ± 8.2 | 0.36 |
International normalized ratio (INR) | 1.12 ± 0.8 | 1.12 ± 2.9 | 1.21 ± 5.5 | 0.42 |
Mg (mg/dL) | 2.11 ± 2.4 | 1.92 ± 1.9 | 1.9 ± 1.9 | 0.40 |
K (mEq/L) | 4.28 ± 2.5 | 4.20 ± 2.5 | 4.18 ± 2.8 | 0.41 |
RDW (%) | 13.9. ± 3.1 | 12.5 ± 3.5 | 16 ± 4.1 | 0.0003 |
FERRITIN (ng/mL) | 216.2 ± 3.5 | 232.5 ± 6.2 | 286 ± 2.7 | <0.0001 |
SIDERAEMIA | 82 ± 2.8 | 81 ± 3.2 | 75 ± 4.6 | 0.04 |
Variables | Group 0 | Group 1 | p-Value ^ |
---|---|---|---|
Hemoglobin, HB (g/dL) (mean ± SD) | 13.5 ± 4.1 | 11.5 ± 2.6 | 0.01 |
PLT 103/µL | 20 ± 4.9 | 24 ± 6.1 | <0.0001 |
CREATININE (mg/dL) | 1.02 ± 5.6 | 1.14 ± 5.6 | 0.49 |
International normalized ratio (INR) | 1.03 ± 1.5 | 1.11 ± 3.2 | 0.48 |
Mg (mg/dL) | 1.83 ± 1.8 | 1.8 ± 4.1 | 0.48 |
K (mEq/L) | 4.10 ± 1.5 | 4.08 ± 2.4 | 0.49 |
RDW (%) | 13.2 ± 3.1 | 16.0 ± 4.2 | 0.04 |
SIDERAEMIA | 86 ± 6.1 | 80 ± 3.1 | <0.0001 |
Variables | Group 1 | Group 0 | ||||
---|---|---|---|---|---|---|
Mean serum ferritin | PWd | P-max | P-min | Pwd | P-max | P-min |
Pearson correlation | 0.89 | 0.88 | 0.83 | 0.66 | 0.41 | 0.38 |
p value | 0.0001 | 0.0001 | 0.0001 | 0.046 | 0.059 | 0.061 |
RDW (%) | ||||||
Pearson correlation | 0.79 | 0.77 | 0.71 | 0.51 | 0.40 | 0.37 |
p value | 0.0002 | 0.0002 | 0.0002 | 0.06 | 0.06 | 0.07 |
Structural Heart Disease Variables * | ||||
---|---|---|---|---|
Left atrial volume index >34 mL/m2 | PWd 1.49 (1.36–1.76) § | P-max 1.45 (1.29–1.74) § | P-min 1.29 (1.29–1.74) § | IAB 1.29 (1.29–1.74) § |
Left ventricular mass index >115 g/m2 for men, >95 g/m2 for women | 1.61 (1.42–1.88) § | 1.09 (1.01–1.41) ‡ | 1.06 (1.74–2.43) ‡ | 1.02 (1.01–1.14) ‡ |
Left ventricular end diastolic diameter >5.8 cm for men, >5.2 cm for women | 2.25 (1.65–3.22) § | 1.52 (1.24–2.18) § | 1.39 (1.24–2.08) § | 1.19 (1.01–1.64) § |
Left ventricular ejection fraction <52% for men, <54% for female | 1.36 (1.16–1.69) § | 1.18 (1.05–1.27) ‡ | 1.12(1.10–1.34) ‡ | 0.29 (1.29–1.74) § |
LAGLS %, difference (95% CI) | −1.59 (−2.33, −0.77) § | −1.19 (−1.86, −0.33)§ | −1.10 (−1.86, −0.33) § | −1.29 (1.29–1.74) § |
LAEF %, difference (95% CI) | −2.79 (−3.29, −1.60) § | −1.17 (−3.01, −0.30) ‡ | −0.06 (−1.48, 1.32) | −1.97 (−4.85, 2.01) |
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Altieri, C.; Pisano, C.; Vincenzo, L.; Ferrante, M.S.; Pellerito, V.; Nardi, P.; Bassano, C.; Buioni, D.; Greco, E.; Ruvolo, G.; et al. Circulating Levels of Ferritin, RDW, PTLs as Predictive Biomarkers of Postoperative Atrial Fibrillation Risk after Cardiac Surgery in Extracorporeal Circulation. Int. J. Mol. Sci. 2022, 23, 14800. https://doi.org/10.3390/ijms232314800
Altieri C, Pisano C, Vincenzo L, Ferrante MS, Pellerito V, Nardi P, Bassano C, Buioni D, Greco E, Ruvolo G, et al. Circulating Levels of Ferritin, RDW, PTLs as Predictive Biomarkers of Postoperative Atrial Fibrillation Risk after Cardiac Surgery in Extracorporeal Circulation. International Journal of Molecular Sciences. 2022; 23(23):14800. https://doi.org/10.3390/ijms232314800
Chicago/Turabian StyleAltieri, Claudia, Calogera Pisano, Labriola Vincenzo, Maria Sabrina Ferrante, Valentina Pellerito, Paolo Nardi, Carlo Bassano, Dario Buioni, Ernesto Greco, Giovanni Ruvolo, and et al. 2022. "Circulating Levels of Ferritin, RDW, PTLs as Predictive Biomarkers of Postoperative Atrial Fibrillation Risk after Cardiac Surgery in Extracorporeal Circulation" International Journal of Molecular Sciences 23, no. 23: 14800. https://doi.org/10.3390/ijms232314800