The role of Mitochondrial Fission Proteins in Mitochondrial Dynamics in Kidney Disease
Abstract
:1. Introduction
2. Mitochondrial Dynamics
2.1. Mitochondrial Fission
2.2. Mitochondrial Fusion
2.3. Cristae Remodeling
2.4. Mitochondrial Dynamics with Other Cellular Organelles
2.4.1. Endoplasmic Reticulum
2.4.2. Lysosomes
2.4.3. Golgi
2.4.4. Actin
2.5. ROS in Mitochondrial Dynamics
3. Structure and Function of Mitochondrial Fission Proteins FIS1/DRP1 and the Role of Post-Translational Modifications
3.1. FIS1
3.1.1. Structure and Function of FIS1
3.1.2. Post-Translational Modifications of FIS1 during Mitochondrial Fission
Phosphorylation
Ubiquitination
SUMOylation
Acetylation
3.2. DRP1
3.2.1. Structure and Function of DRP1
3.2.2. Post-Translational Modifications of DRP1 during Mitochondrial Fission
Phosphorylation
Ubiquitination
SUMOization
O-GlcNAcylation
Acetylation
S-Nitrosylation
4. FIS1- and DRP1-Dependent Mitochondrial Dynamics in Kidney Disease
4.1. Acute Kidney Injury (AKI)
4.2. Chronic Kidney Disease (CKD)
4.3. Diabetic Kidney Disease (DKD)
5. Drugs Targeting FIS1 and DRP1 and Their Role in Kidney Disease
6. Summary and Outlook
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Type of Modification | Position | Upstream Molecules | Effects |
---|---|---|---|
Phosphorylation | Y38 | MET | Phosphorylation |
/ | DNA-PKcs | Phosphorylation | |
Ubiquitination | / | Parkin | Ubiquitination |
/ | MARCH5 | Ubiquitination | |
SUMOylation | K149 | SENP3 | DeSUMOylation |
Acetylation | / | SIRT3 | DeAcetylation |
Type of Modification | Position | Upstream Molecules | Effects |
---|---|---|---|
Phosphorylation | Ser-616 | Stat2 | Phosphorylation |
PKCδ | Phosphorylation | ||
ERK1/2 | Phosphorylation | ||
CaMKII | Phosphorylation | ||
Cdk5 | Phosphorylation | ||
ROCK | Phosphorylation | ||
DUSP6 | DePhosphorylation | ||
Ser-637 | PKA | The specific role of S637 phosphorylation results from diverse internal and external parameters | |
PKD | |||
CaN | |||
AMPK | |||
Ubiquitination | / | Parkin | Ubiquitination |
/ | MARCH5 | Ubiquitination | |
/ | SQSTM1/P62 | Ubiquitination | |
SUMOylation | / | SENP3 | DeSUMOylation |
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Qin, L.; Xi, S. The role of Mitochondrial Fission Proteins in Mitochondrial Dynamics in Kidney Disease. Int. J. Mol. Sci. 2022, 23, 14725. https://doi.org/10.3390/ijms232314725
Qin L, Xi S. The role of Mitochondrial Fission Proteins in Mitochondrial Dynamics in Kidney Disease. International Journal of Molecular Sciences. 2022; 23(23):14725. https://doi.org/10.3390/ijms232314725
Chicago/Turabian StyleQin, Lingyu, and Shuhua Xi. 2022. "The role of Mitochondrial Fission Proteins in Mitochondrial Dynamics in Kidney Disease" International Journal of Molecular Sciences 23, no. 23: 14725. https://doi.org/10.3390/ijms232314725