Therapeutic Potential of Extracellular Vesicles in Aging and Age-Related Diseases
Abstract
:1. Introduction
2. Role of EVs in the Aging Process
2.1. Cellular Senescence
2.2. Oxidative Stress
2.3. Telomere Dysfunction
2.4. Autophagy
2.5. Inflammation
2.6. Metabolism
3. Pro-Regenerative Effects of EVs
3.1. Effects of EVs on the Nervous Tissue
3.2. Effects of EVs on the Cardiovascular System
3.3. Effects of EVs on the Musculoskeletal System
3.4. Effects of EVs on Damaged Lungs
3.5. Effects of EVs on Damaged Kidney
3.6. Effects of EVs on Damaged Liver
4. Therapeutic Potential of EVs in Age-Related Diseases
4.1. Alzheimer’s Disease
4.2. Atherosclerosis
4.3. Type 2 Diabetes
4.4. Osteoporosis
4.5. Osteoarthritis
4.6. Chronic Kidney Disease
4.7. Frailty
5. Overview
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
References
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References | Tissue | Effect | Pathway Involved |
---|---|---|---|
[69] | Brain | Neuroprotective effect in ischemia and traumatic brain injury | Activation of PI3K/AKT pathway and calcium oscillations |
[70] | Brain | Decrease in neuronal apoptosis and motor recovery | Activation of Wnt/β-catenin signaling |
[71] | Heart | Enhanced myocardial viability in ischemia/reperfusion | Activation of PI3K/AKT pathway and reduced phosphorylated-c-JNK |
[10,72,73] | Endothelial cells | Improved angiogenesis | Activation of VEGF signaling and PI3K/AKT, repression of ATM |
[74] | Muscle | Prevention of muscle damage in hind limb ischemia | Activation of Neuregulin-1 |
[74] | Muscle | Improved myogenesis | Increased IGFs, HGFs and FGFs |
[75] | Muscle | Improved muscle regeneration in aging | Activation of Klotho pathway |
[76] | Bone | Decrease in radiation-induced bone loss | Activation of Wnt/β-catenin signaling |
[77] | Bone | Improved bone regeneration | Activation of AKT/mTOR pathway |
[78] | Lung | Amelioration of acute lung injury | Induction of RPTOR/mTOR pathway |
[79] | Lung | Antifibrotic effect in a model of pulmonary fibrosis | Inhibition of TGF-β-Wnt crosstalk |
[80] | Kidney | Decreased kidney injury in ischemia/reperfusion | Inhibition of CCL2 pathway |
[81] | Liver | Amelioration of hepatic ischemia/reperfusion injury | Inhibition of MEK/ERK pathway |
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Sanz-Ros, J.; Mas-Bargues, C.; Romero-García, N.; Huete-Acevedo, J.; Dromant, M.; Borrás, C. Therapeutic Potential of Extracellular Vesicles in Aging and Age-Related Diseases. Int. J. Mol. Sci. 2022, 23, 14632. https://doi.org/10.3390/ijms232314632
Sanz-Ros J, Mas-Bargues C, Romero-García N, Huete-Acevedo J, Dromant M, Borrás C. Therapeutic Potential of Extracellular Vesicles in Aging and Age-Related Diseases. International Journal of Molecular Sciences. 2022; 23(23):14632. https://doi.org/10.3390/ijms232314632
Chicago/Turabian StyleSanz-Ros, Jorge, Cristina Mas-Bargues, Nekane Romero-García, Javier Huete-Acevedo, Mar Dromant, and Consuelo Borrás. 2022. "Therapeutic Potential of Extracellular Vesicles in Aging and Age-Related Diseases" International Journal of Molecular Sciences 23, no. 23: 14632. https://doi.org/10.3390/ijms232314632