Gene- and Gender-Related Decrease in Serum BDNF Levels in Alzheimer’s Disease
Abstract
:1. Introduction
2. Results
2.1. Patients
2.2. Serum BDNF
2.3. Alleles, Genotypes and Haplotypes
2.4. BDNF (Val66Met, C270T), IL-1α Gene Polymorphisms and Serum Levels of BDNF
3. Discussion
4. Materials and Methods
4.1. Patients
4.2. Serum Collection, DNA Extraction and SNP Genotyping
4.3. Enzyme-Linked Immunosorbent Assay for Detection of BDNF
4.4. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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AD (n = 79) | MCI (n = 31) | p | |
---|---|---|---|
Age at diagnosis, mean ± SD, years | 73.79 ± 8.54, 55–92 | 67.59 ± 9.83, 43–84 | 0.002 |
Age at study, mean ± SD, Years 1 | 76.41 ± 8.12, 50–89 | 68.71 ± 9.68, 43–84 | <0.001 |
Mean period from diagnosis, mean ± SD, years | 2.47 ± 2.31, 0–11 | 1.19 ± 1.55, 0–5 | 0.009 |
Gender 2 n, % | M = 29, 36.7% F = 50, 63.3% | M = 8, 25.8%; F = 23, 74.2% | ns |
Early onset (<65 years), n, % | n = 8, 10.1% | n = 11, 35.5% | 0.004 |
Positive family history, n, % | 14, 17.7% | 10, 32.3% | ns |
Disease duration, years | 0–11 | 0–5 | - |
MMSE score, (range) | 16.68 ± 6.22 (2–27) | 24.46 ± 5.27 (6–30) | <0.001 |
APOE4+ genotypes 3 n, % | 37, 46.8% | 9, 29.0% | ns |
AD n = 71 | MCI n = 31 | Controls n = 32 | p 1 | |
---|---|---|---|---|
Serum BDNF (pg/mL) | 11.97 ± 2.24 | 12.63 ± 2.19 | 12.88 ± 1.51 | 0.029 2 |
Gender | ||||
M | 12.47 ± 1.68 | 12.45 ± 2.23 | 12.56 ± 1.38 | ns |
F | 11.70 ± 2.46 | 12.70 ± 2.23 | 13.05 ± 1.58 | 0.005 3 |
BDNFVal66Met | ||||
Val/Val | 11.78 ± 2.40 | 12.63 ± 2.43 | 13.21 ± 1.19 | 0.026 4 |
Met/Met + Val/Met | 12.45 ± 1.88 | 12.53 ± 1.76 | 12.46 ± 1.80 | ns |
BDNF 270C < T | ||||
C/C | 12.10 ± 2.23 | 12.28 ± 2.26 | 12.79 ± 1.62 | ns |
C/T | 12.82 ± 1.11 | 14.74± 0.30 | 13.31 ± 0.62 | 0.035 5 |
IL-1α rs1800587 | ||||
T/T + T/C | 11.44 ± 2.60 | 12.53 ± 1.93 | 12.62 ± 1.80 | ns 6 |
C/C | 12.69 ± 1.35 | 12.77 ± 2.58 | 13.38 ± 0.39 | ns |
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Piancatelli, D.; Aureli, A.; Sebastiani, P.; Colanardi, A.; Del Beato, T.; Del Cane, L.; Sucapane, P.; Marini, C.; Di Loreto, S. Gene- and Gender-Related Decrease in Serum BDNF Levels in Alzheimer’s Disease. Int. J. Mol. Sci. 2022, 23, 14599. https://doi.org/10.3390/ijms232314599
Piancatelli D, Aureli A, Sebastiani P, Colanardi A, Del Beato T, Del Cane L, Sucapane P, Marini C, Di Loreto S. Gene- and Gender-Related Decrease in Serum BDNF Levels in Alzheimer’s Disease. International Journal of Molecular Sciences. 2022; 23(23):14599. https://doi.org/10.3390/ijms232314599
Chicago/Turabian StylePiancatelli, Daniela, Anna Aureli, Pierluigi Sebastiani, Alessia Colanardi, Tiziana Del Beato, Lorenza Del Cane, Patrizia Sucapane, Carmine Marini, and Silvia Di Loreto. 2022. "Gene- and Gender-Related Decrease in Serum BDNF Levels in Alzheimer’s Disease" International Journal of Molecular Sciences 23, no. 23: 14599. https://doi.org/10.3390/ijms232314599