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Volume 23
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10.3390/ijms232012156
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Article

Excessive Adventitial and Perivascular Vascularisation Correlates with Vascular Inflammation and Intimal Hyperplasia

by
Leo Bogdanov
,
Daria Shishkova
,
Rinat Mukhamadiyarov
,
Elena Velikanova
,
Anna Tsepokina
,
Alexander Terekhov
,
Vladislav Koshelev
,
Anastasia Kanonykina
,
Amin Shabaev
,
Alexey Frolov
,
Nikita Zagorodnikov
and
Anton Kutikhin
*
Department of Experimental Medicine, Research Institute for Complex Issues of Cardiovascular Diseases, 6 Sosnovy Boulevard, 650002 Kemerovo, Russia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(20), 12156; https://doi.org/10.3390/ijms232012156
Submission received: 2 September 2022 / Revised: 9 October 2022 / Accepted: 10 October 2022 / Published: 12 October 2022
(This article belongs to the Special Issue Atherosclerosis: From Molecular Biology to Therapeutic Perspective 3.0)
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Abstract

Albeit multiple studies demonstrated that vasa vasorum (VV) have a crucial importance in vascular pathology, the informative markers and metrics of vascular inflammation defining the development of intimal hyperplasia (IH) have been vaguely studied. Here, we employed two rat models (balloon injury of the abdominal aorta and the same intervention optionally complemented with intravenous injections of calciprotein particles) and a clinical scenario (arterial and venous conduits for coronary artery bypass graft (CABG) surgery) to investigate the pathophysiological interconnections among VV, myeloperoxidase-positive (MPO+) clusters, and IH. We found that the amounts of VV and MPO+ clusters were strongly correlated; further, MPO+ clusters density was significantly associated with balloon-induced IH and increased at calciprotein particle-provoked endothelial dysfunction. Likewise, number and density of VV correlated with IH in bypass grafts for CABG surgery at the pre-intervention stage and were higher in venous conduits which more frequently suffered from IH as compared with arterial grafts. Collectively, our results underline the pathophysiological importance of excessive VV upon the vascular injury or at the exposure to cardiovascular risk factors, highlight MPO+ clusters as an informative marker of adventitial and perivascular inflammation, and propose another mechanistic explanation of a higher long-term patency of arterial grafts upon the CABG surgery.
Keywords: vasa vasorum; tunica adventitia; perivascular adipose tissue; vascular inflammation; intimal hyperplasia; coronary artery bypass graft surgery; internal mammary arteries; saphenous veins vasa vasorum; tunica adventitia; perivascular adipose tissue; vascular inflammation; intimal hyperplasia; coronary artery bypass graft surgery; internal mammary arteries; saphenous veins

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MDPI and ACS Style

Bogdanov, L.; Shishkova, D.; Mukhamadiyarov, R.; Velikanova, E.; Tsepokina, A.; Terekhov, A.; Koshelev, V.; Kanonykina, A.; Shabaev, A.; Frolov, A.; et al. Excessive Adventitial and Perivascular Vascularisation Correlates with Vascular Inflammation and Intimal Hyperplasia. Int. J. Mol. Sci. 2022, 23, 12156. https://doi.org/10.3390/ijms232012156

AMA Style

Bogdanov L, Shishkova D, Mukhamadiyarov R, Velikanova E, Tsepokina A, Terekhov A, Koshelev V, Kanonykina A, Shabaev A, Frolov A, et al. Excessive Adventitial and Perivascular Vascularisation Correlates with Vascular Inflammation and Intimal Hyperplasia. International Journal of Molecular Sciences. 2022; 23(20):12156. https://doi.org/10.3390/ijms232012156

Chicago/Turabian Style

Bogdanov, Leo, Daria Shishkova, Rinat Mukhamadiyarov, Elena Velikanova, Anna Tsepokina, Alexander Terekhov, Vladislav Koshelev, Anastasia Kanonykina, Amin Shabaev, Alexey Frolov, and et al. 2022. "Excessive Adventitial and Perivascular Vascularisation Correlates with Vascular Inflammation and Intimal Hyperplasia" International Journal of Molecular Sciences 23, no. 20: 12156. https://doi.org/10.3390/ijms232012156

APA Style

Bogdanov, L., Shishkova, D., Mukhamadiyarov, R., Velikanova, E., Tsepokina, A., Terekhov, A., Koshelev, V., Kanonykina, A., Shabaev, A., Frolov, A., Zagorodnikov, N., & Kutikhin, A. (2022). Excessive Adventitial and Perivascular Vascularisation Correlates with Vascular Inflammation and Intimal Hyperplasia. International Journal of Molecular Sciences, 23(20), 12156. https://doi.org/10.3390/ijms232012156

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