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Volume 23
Issue 2
10.3390/ijms23020994
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Review
Peer-Review Record

Shigella Outer Membrane Vesicles as Promising Targets for Vaccination

Int. J. Mol. Sci. 2022, 23(2), 994; https://doi.org/10.3390/ijms23020994
by Muhammad Qasim 1, Marius Wrage 2, Björn Nüse 2 and Jochen Mattner 2,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2022, 23(2), 994; https://doi.org/10.3390/ijms23020994
Submission received: 28 December 2021 / Revised: 11 January 2022 / Accepted: 14 January 2022 / Published: 17 January 2022
(This article belongs to the Special Issue Inflammatory Bowel Disease: From Pre-clinial Models into Translation)

Round 1

Reviewer 1 Report

Thank you for the opportunity to review this comprehensive review article. Authors have reviewed Shigella outer membrane vesicles (OMVs) as a target for needed vaccination possibility.

Article is well written, with good flow of information and understandable reading. I have just a few minor comments:

In chapter 3, more detailed information should be put regarding previous studies that investigated vaccination approaches, to further confirm the main idea of this review

Line 195 – you can put reference numbers instead Pastor et al and Camacho et al

All tables could be adjusted and aligned better, as well as be wider and more reader-friendly

Lines 313-341 – This part could be re-written to be more comprehensive, as it has a number of small unneeded paragraphs

Author Response

Please find the point by point reply attached

Author Response File: Author Response.docx

Reviewer 2 Report

  • “the mortality rate of shigellosis can be high”

 

In what circumstances?

 

  • Use oxford comma in the whole text

 

  • “to commonly used frontline antibiotics”

 

Please specify

 

  • Which is the species most prevalent in developed countries?

 

  • “Importantly, these OMVs also elicited 100% protection against shigellosis”

 

Specify in mice model; specify against what species

 

  • Why vaccines efficacious in mice are not used (after trails) in humans?

Author Response

Please find the point by point reply attached

Author Response File: Author Response.docx

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