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Correction published on 28 February 2025, see Int. J. Mol. Sci. 2025, 26(5), 2165.
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Article

The Effect of Long-Lasting Swimming on Rats Skeletal Muscles Energy Metabolism after Nine Days of Dexamethasone Treatment

by
Damian Jozef Flis
1,*,
Emilia Gabriela Bialobrodzka
2,
Ewa Aleksandra Rodziewicz-Flis
3,
Zbigniew Jost
4,
Andzelika Borkowska
5,
Wieslaw Ziolkowski
6,† and
Jan Jacek Kaczor
7,†
1
Department of Pharmaceutical Pathophysiology, Faculty of Pharmacy, Medical University of Gdansk, Dębinki 7 Street, 80-211 Gdansk, Poland
2
Poznan University of Physical Education, Królowej Jadwigi 27/39 Street, 61-871 Poznan, Poland
3
Department of Basic Physiotherapy, Gdansk University of Physical Education and Sport, K. Gorkiego 1 Street, 80-336 Gdansk, Poland
4
Department of Biochemistry, Gdansk University of Physical Education and Sport, K. Gorkiego 1 Street, 80-336 Gdansk, Poland
5
Department of Bioenergetics and Physiology of Exercise, Faculty of Health Sciences, Medical University of Gdansk, Dębinki 1 Street, 80-211 Gdansk, Poland
6
Department of Rehabilitation Medicine, Faculty of Health Sciences, Medical University of Gdansk, Al. Zwycięstwa 30, 80-219 Gdansk, Poland
7
Department of Animal and Human Physiology, University of Gdansk, J. Bazynskiego 8 Street, 80-308 Gdansk, Poland
*
Author to whom correspondence should be addressed.
†
These authors should be considered as senior author.
Int. J. Mol. Sci. 2022, 23(2), 748; https://doi.org/10.3390/ijms23020748
Submission received: 30 November 2021 / Revised: 4 January 2022 / Accepted: 8 January 2022 / Published: 11 January 2022 / Corrected: 28 February 2025
(This article belongs to the Special Issue Molecular and Cellular Exercise Physiology in Metabolism)
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Abstract

This study investigates the effect of Dexamethasone (Dex) treatment on blood and skeletal muscle metabolites level and skeletal muscle activity of enzymes related to energy metabolism after long-duration swimming. To evaluate whether Dex treatment, swimming, and combining these factors act on analyzed data, rats were randomly divided into four groups: saline treatment non-exercise and exercise and Dex treatment non-exercised and exercised. Animals in both exercised groups underwent long-lasting swimming. The concentration of lipids metabolites, glucose, and lactate were measured in skeletal muscles and blood according to standard colorimetric and fluorimetric methods. Also, activities of enzymes related to aerobic and anaerobic metabolism were measured in skeletal muscles. The results indicated that Dex treatment induced body mass loss and increased lipid metabolites in the rats’ blood but did not alter these changes in skeletal muscles. Interestingly, prolonged swimming applied after 9 days of Dex treatment significantly intensified changes induced by Dex; however, there was no difference in skeletal muscle enzymatic activities. This study shows for the first time the cumulative effect of exercise and Dex on selected elements of lipid metabolism, which seems to be essential for the patient’s health due to the common use of glucocorticoids like Dex.
Keywords: dexamethasone; endurance exercise; lipid metabolism; glucose metabolism; skeletal muscle dexamethasone; endurance exercise; lipid metabolism; glucose metabolism; skeletal muscle

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MDPI and ACS Style

Flis, D.J.; Bialobrodzka, E.G.; Rodziewicz-Flis, E.A.; Jost, Z.; Borkowska, A.; Ziolkowski, W.; Kaczor, J.J. The Effect of Long-Lasting Swimming on Rats Skeletal Muscles Energy Metabolism after Nine Days of Dexamethasone Treatment. Int. J. Mol. Sci. 2022, 23, 748. https://doi.org/10.3390/ijms23020748

AMA Style

Flis DJ, Bialobrodzka EG, Rodziewicz-Flis EA, Jost Z, Borkowska A, Ziolkowski W, Kaczor JJ. The Effect of Long-Lasting Swimming on Rats Skeletal Muscles Energy Metabolism after Nine Days of Dexamethasone Treatment. International Journal of Molecular Sciences. 2022; 23(2):748. https://doi.org/10.3390/ijms23020748

Chicago/Turabian Style

Flis, Damian Jozef, Emilia Gabriela Bialobrodzka, Ewa Aleksandra Rodziewicz-Flis, Zbigniew Jost, Andzelika Borkowska, Wieslaw Ziolkowski, and Jan Jacek Kaczor. 2022. "The Effect of Long-Lasting Swimming on Rats Skeletal Muscles Energy Metabolism after Nine Days of Dexamethasone Treatment" International Journal of Molecular Sciences 23, no. 2: 748. https://doi.org/10.3390/ijms23020748

APA Style

Flis, D. J., Bialobrodzka, E. G., Rodziewicz-Flis, E. A., Jost, Z., Borkowska, A., Ziolkowski, W., & Kaczor, J. J. (2022). The Effect of Long-Lasting Swimming on Rats Skeletal Muscles Energy Metabolism after Nine Days of Dexamethasone Treatment. International Journal of Molecular Sciences, 23(2), 748. https://doi.org/10.3390/ijms23020748

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