Omega-6 and Omega-3 Fatty Acid-Derived Oxylipins from the Lipoxygenase Pathway in Maternal and Umbilical Cord Plasma at Delivery and Their Relationship with Infant Growth

Thompson, Maranda; Ulu, Arzu; Yuil-Valdes, Ana G.; Mukherjee, Maheswari; Thoene, Melissa; Van Ormer, Matthew; Slotkowski, Rebecca; Lyden, Elizabeth; Anderson Berry, Ann; Hanson, Corrine K.; Nordgren, Tara M.; Natarajan, Sathish Kumar

doi:10.3390/ijms23020708

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Omega-6 and Omega-3 Fatty Acid-Derived Oxylipins from the Lipoxygenase Pathway in Maternal and Umbilical Cord Plasma at Delivery and Their Relationship with Infant Growth

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Sathish Kumar Natarajan

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Pediatrics Department, University of Nebraska Medical Center, Omaha, NE 68198, USA

Division of Biomedical Sciences, University of California Riverside, Riverside, CA 92521, USA

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA

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Cytotechnology Education, College of Allied Health Professions, University of Nebraska Medical Center, Omaha, NE 68198, USA

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Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198, USA

⁶

Medical Nutrition Education, College of Allied Health Profession, University of Nebraska Medical Center, Omaha, NE 68198, USA

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Department of Environmental and Radiological Health Science, Colorado State University, Fort Collins, CO 80525, USA

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Department of Nutrition & Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA

Author to whom correspondence should be addressed.

Academic Editors: Gijs Kooij and Valerio Chiurchiù

Int. J. Mol. Sci. 2022, 23(2), 708; https://doi.org/10.3390/ijms23020708

Received: 1 December 2021 / Revised: 24 December 2021 / Accepted: 28 December 2021 / Published: 9 January 2022

(This article belongs to the Special Issue Advances in Lipid-Mediated Inflammation-Resolution Mechanisms in Health and Disease)

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Abstract

Omega-3 and omega-6 fatty acids are important for neonatal development and health. One mechanism by which omega-3 and omega-6 fatty acids exert their effects is through their metabolism into oxylipins and specialized pro-resolving mediators. However, the influence of oxylipins on fetal growth is not well understood. Therefore, the objective of this study was to identify oxylipins present in maternal and umbilical cord plasma and investigate their relationship with infant growth. Liquid chromatography–tandem mass spectrometry was used to quantify oxylipin levels in plasma collected at the time of delivery. Spearman’s correlations highlighted significant correlations between metabolite levels and infant growth. They were then adjusted for maternal obesity (normal body mass index (BMI: ≤30 kg/m²) vs. obese BMI (>30 kg/m²) and smoking status (never vs. current/former smoker) using linear regression modeling. A p-value < 0.05 was considered statistically significant. Our study demonstrated a diverse panel of oxylipins from the lipoxygenase pathway present at the time of delivery. In addition, both omega-3 and omega-6 oxylipins demonstrated potential influences on the birth length and weight percentiles. The oxylipins present during pregnancy may influence fetal growth and development, suggesting potential metabolites to be used as biomarkers for infant outcomes. View Full-Text

Keywords: omega-3 fatty acids; omega-6 fatty acids; metabolites; oxylipins; plasma; delivery; infant growth; inflammation; lipoxygenase; birth weight percentile; birth length percentile; birth head circumference percentile

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Thompson, M.; Ulu, A.; Yuil-Valdes, A.G.; Mukherjee, M.; Thoene, M.; Van Ormer, M.; Slotkowski, R.; Lyden, E.; Anderson Berry, A.; Hanson, C.K.; Nordgren, T.M.; Natarajan, S.K. Omega-6 and Omega-3 Fatty Acid-Derived Oxylipins from the Lipoxygenase Pathway in Maternal and Umbilical Cord Plasma at Delivery and Their Relationship with Infant Growth. Int. J. Mol. Sci. 2022, 23, 708. https://doi.org/10.3390/ijms23020708

AMA Style

Thompson M, Ulu A, Yuil-Valdes AG, Mukherjee M, Thoene M, Van Ormer M, Slotkowski R, Lyden E, Anderson Berry A, Hanson CK, Nordgren TM, Natarajan SK. Omega-6 and Omega-3 Fatty Acid-Derived Oxylipins from the Lipoxygenase Pathway in Maternal and Umbilical Cord Plasma at Delivery and Their Relationship with Infant Growth. International Journal of Molecular Sciences. 2022; 23(2):708. https://doi.org/10.3390/ijms23020708

Chicago/Turabian Style

Thompson, Maranda, Arzu Ulu, Ana G. Yuil-Valdes, Maheswari Mukherjee, Melissa Thoene, Matthew Van Ormer, Rebecca Slotkowski, Elizabeth Lyden, Ann Anderson Berry, Corrine K. Hanson, Tara M. Nordgren, and Sathish K. Natarajan. 2022. "Omega-6 and Omega-3 Fatty Acid-Derived Oxylipins from the Lipoxygenase Pathway in Maternal and Umbilical Cord Plasma at Delivery and Their Relationship with Infant Growth" International Journal of Molecular Sciences 23, no. 2: 708. https://doi.org/10.3390/ijms23020708

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Omega-6 and Omega-3 Fatty Acid-Derived Oxylipins from the Lipoxygenase Pathway in Maternal and Umbilical Cord Plasma at Delivery and Their Relationship with Infant Growth

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