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Perspective

A Structural Perspective on the RNA Editing of Plant Respiratory Complexes

Department of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA
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Authors to whom correspondence should be addressed.
Academic Editors: Víctor Quesada and Pedro Robles
Int. J. Mol. Sci. 2022, 23(2), 684; https://doi.org/10.3390/ijms23020684
Received: 18 December 2021 / Revised: 31 December 2021 / Accepted: 5 January 2022 / Published: 8 January 2022
(This article belongs to the Special Issue Organelle Genetics in Plants 2.0)
The last steps of respiration, a core energy-harvesting process, are carried out by a chain of multi-subunit complexes in the inner mitochondrial membrane. Several essential subunits of the respiratory complexes are RNA-edited in plants, frequently leading to changes in the encoded amino acids. While the impact of RNA editing is clear at the sequence and phenotypic levels, the underlying biochemical explanations for these effects have remained obscure. Here, we used the structures of plant respiratory complex I, complex III2 and complex IV to analyze the impact of the amino acid changes of RNA editing in terms of their location and biochemical features. Through specific examples, we demonstrate how the structural information can explain the phenotypes of RNA-editing mutants. This work shows how the structural perspective can bridge the gap between sequence and phenotype and provides a framework for the continued analysis of RNA-editing mutants in plant mitochondria and, by extension, in chloroplasts. View Full-Text
Keywords: plant respiration; plant mitochondria; RNA editing; structure-function plant respiration; plant mitochondria; RNA editing; structure-function
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MDPI and ACS Style

Maldonado, M.; Abe, K.M.; Letts, J.A. A Structural Perspective on the RNA Editing of Plant Respiratory Complexes. Int. J. Mol. Sci. 2022, 23, 684. https://doi.org/10.3390/ijms23020684

AMA Style

Maldonado M, Abe KM, Letts JA. A Structural Perspective on the RNA Editing of Plant Respiratory Complexes. International Journal of Molecular Sciences. 2022; 23(2):684. https://doi.org/10.3390/ijms23020684

Chicago/Turabian Style

Maldonado, Maria, Kaitlyn M. Abe, and James A. Letts. 2022. "A Structural Perspective on the RNA Editing of Plant Respiratory Complexes" International Journal of Molecular Sciences 23, no. 2: 684. https://doi.org/10.3390/ijms23020684

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