Normal and Aberrant TALE-Class Homeobox Gene Activities in Pro-B-Cells and B-Cell Precursor Acute Lymphoblastic Leukemia
Abstract
:1. Introduction
2. Results
2.1. TALE Homeobox Gene Activities in Early B-Cell Development
2.2. Aberrant Expression of IRX2, IRX3 and MEIS1 in BCP-ALL Patients and Cell Lines
2.3. E2F1 and TCF3 Are Regulators and Targets of IRX1 and IRX2 in BCP-ALL
2.4. IRX3 Regulates ETV6 and KLF15 Regulates IRX3 in BCP-ALL
2.5. MEIS1 Activates Expression of IRX3 in BCP-ALL
2.6. Functional Analysis of IRX2 and IRX3 in BCP-ALL
3. Discussion
4. Materials and Methods
4.1. Analysis of Expression Profiling and RNA-Seq Data
4.2. Cell Lines and Treatments
4.3. Polymerase Chain Reaction (PCR) Analyses
4.4. Reporter Gene Assays
4.5. Protein Analysis
4.6. Genomic Profiling Analysis
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Nagel, S.; Meyer, C. Normal and Aberrant TALE-Class Homeobox Gene Activities in Pro-B-Cells and B-Cell Precursor Acute Lymphoblastic Leukemia. Int. J. Mol. Sci. 2022, 23, 11874. https://doi.org/10.3390/ijms231911874
Nagel S, Meyer C. Normal and Aberrant TALE-Class Homeobox Gene Activities in Pro-B-Cells and B-Cell Precursor Acute Lymphoblastic Leukemia. International Journal of Molecular Sciences. 2022; 23(19):11874. https://doi.org/10.3390/ijms231911874
Chicago/Turabian StyleNagel, Stefan, and Corinna Meyer. 2022. "Normal and Aberrant TALE-Class Homeobox Gene Activities in Pro-B-Cells and B-Cell Precursor Acute Lymphoblastic Leukemia" International Journal of Molecular Sciences 23, no. 19: 11874. https://doi.org/10.3390/ijms231911874