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Article

Highly Bright Silica-Coated InP/ZnS Quantum Dot-Embedded Silica Nanoparticles as Biocompatible Nanoprobes

by
Kyeong-Min Ham
1,†,
Minhee Kim
1,†,
Sungje Bock
1,
Jaehi Kim
1,
Wooyeon Kim
1,
Heung Su Jung
2,
Jaehyun An
1,3,
Hobeom Song
3,
Jung-Won Kim
3,
Hyung-Mo Kim
1,4,
Won-Yeop Rho
5,
Sang Hun Lee
6,
Seung-min Park
7,
Dong-Eun Kim
1,* and
Bong-Hyun Jun
1,*
1
Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Korea
2
Company of Global Zeus, Hwaseong 18363, Korea
3
Company of BioSquare, Hwaseong 18449, Korea
4
AI-Superconvergence KIURI Translational Research Center, Ajou University School of Medicine, Suwon 16499, Korea
5
School of International Engineering and Science, Jeonbuk National University, Jeonju 54896, Korea
6
Department of Chemical and Biological Engineering, Hanbat University, Daejeon 34158, Korea
7
Department of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2022, 23(18), 10977; https://doi.org/10.3390/ijms231810977
Submission received: 24 August 2022 / Revised: 15 September 2022 / Accepted: 16 September 2022 / Published: 19 September 2022
(This article belongs to the Special Issue Advanced Optical Materials: From Materials to Applications)
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Abstract

Quantum dots (QDs) have outstanding optical properties such as strong fluorescence, excellent photostability, broad absorption spectra, and narrow emission bands, which make them useful for bioimaging. However, cadmium (Cd)-based QDs, which have been widely studied, have potential toxicity problems. Cd-free QDs have also been studied, but their weak photoluminescence (PL) intensity makes their practical use in bioimaging challenging. In this study, Cd-free QD nanoprobes for bioimaging were fabricated by densely embedding multiple indium phosphide/zinc sulfide (InP/ZnS) QDs onto silica templates and coating them with a silica shell. The fabricated silica-coated InP/ZnS QD-embedded silica nanoparticles (SiO2@InP QDs@SiO2 NPs) exhibited hydrophilic properties because of the surface silica shell. The quantum yield (QY), maximum emission peak wavelength, and full-width half-maximum (FWHM) of the final fabricated SiO2@InP QDs@SiO2 NPs were 6.61%, 527.01 nm, and 44.62 nm, respectively. Moreover, the brightness of the particles could be easily controlled by adjusting the amount of InP/ZnS QDs in the SiO2@InP QDs@SiO2 NPs. When SiO2@InP QDs@SiO2 NPs were administered to tumor syngeneic mice, the fluorescence signal was prominently detected in the tumor because of the preferential distribution of the SiO2@InP QDs@SiO2 NPs, demonstrating their applicability in bioimaging with NPs. Thus, SiO2@InP QDs@SiO2 NPs have the potential to successfully replace Cd-based QDs as highly bright and biocompatible fluorescent nanoprobes.
Keywords: quantum dots (QDs); silica-coated InP/ZnS QD-embedded silica nanoparticles; biocompatible nanoprobes; photoluminescence (PL); syngeneic mice; in vivo; bioimaging quantum dots (QDs); silica-coated InP/ZnS QD-embedded silica nanoparticles; biocompatible nanoprobes; photoluminescence (PL); syngeneic mice; in vivo; bioimaging
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MDPI and ACS Style

Ham, K.-M.; Kim, M.; Bock, S.; Kim, J.; Kim, W.; Jung, H.S.; An, J.; Song, H.; Kim, J.-W.; Kim, H.-M.; et al. Highly Bright Silica-Coated InP/ZnS Quantum Dot-Embedded Silica Nanoparticles as Biocompatible Nanoprobes. Int. J. Mol. Sci. 2022, 23, 10977. https://doi.org/10.3390/ijms231810977

AMA Style

Ham K-M, Kim M, Bock S, Kim J, Kim W, Jung HS, An J, Song H, Kim J-W, Kim H-M, et al. Highly Bright Silica-Coated InP/ZnS Quantum Dot-Embedded Silica Nanoparticles as Biocompatible Nanoprobes. International Journal of Molecular Sciences. 2022; 23(18):10977. https://doi.org/10.3390/ijms231810977

Chicago/Turabian Style

Ham, Kyeong-Min, Minhee Kim, Sungje Bock, Jaehi Kim, Wooyeon Kim, Heung Su Jung, Jaehyun An, Hobeom Song, Jung-Won Kim, Hyung-Mo Kim, and et al. 2022. "Highly Bright Silica-Coated InP/ZnS Quantum Dot-Embedded Silica Nanoparticles as Biocompatible Nanoprobes" International Journal of Molecular Sciences 23, no. 18: 10977. https://doi.org/10.3390/ijms231810977

APA Style

Ham, K.-M., Kim, M., Bock, S., Kim, J., Kim, W., Jung, H. S., An, J., Song, H., Kim, J.-W., Kim, H.-M., Rho, W.-Y., Lee, S. H., Park, S.-m., Kim, D.-E., & Jun, B.-H. (2022). Highly Bright Silica-Coated InP/ZnS Quantum Dot-Embedded Silica Nanoparticles as Biocompatible Nanoprobes. International Journal of Molecular Sciences, 23(18), 10977. https://doi.org/10.3390/ijms231810977

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