Adiponectin Intervention to Regulate Betatrophin Expression, Attenuate Insulin Resistance and Enhance Glucose Metabolism in Mice and Its Response to Exercise
Abstract
:1. Introduction
2. Results
2.1. Effect of Adiponectin KO on Betatrophin Expression in Liver
2.2. Effects of Exercise on Adiponectin and Betatrophin Expression
2.3. Exercise Affects Betatrophin Expression through the LKB1/AMPK/PGC-1α Pathway
2.4. Exercise Inhibits Betatrophin Expression and Improves Insulin Sensitivity in Obese Mice
3. Discussion
4. Material and Methods
4.1. Mice
4.2. Vector Construction
4.3. Exercise Training
4.4. Measurement of Serum Protein Levels
4.5. Western Blotting
4.6. RNA Extraction and Quantitative Reverse Transcription Quantitative (RT-qPCR)
4.7. Data Analysis and Statistics
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Guo, Q.; Cao, S.; Wang, X. Adiponectin Intervention to Regulate Betatrophin Expression, Attenuate Insulin Resistance and Enhance Glucose Metabolism in Mice and Its Response to Exercise. Int. J. Mol. Sci. 2022, 23, 10630. https://doi.org/10.3390/ijms231810630
Guo Q, Cao S, Wang X. Adiponectin Intervention to Regulate Betatrophin Expression, Attenuate Insulin Resistance and Enhance Glucose Metabolism in Mice and Its Response to Exercise. International Journal of Molecular Sciences. 2022; 23(18):10630. https://doi.org/10.3390/ijms231810630
Chicago/Turabian StyleGuo, Qi, Shicheng Cao, and Xiaohong Wang. 2022. "Adiponectin Intervention to Regulate Betatrophin Expression, Attenuate Insulin Resistance and Enhance Glucose Metabolism in Mice and Its Response to Exercise" International Journal of Molecular Sciences 23, no. 18: 10630. https://doi.org/10.3390/ijms231810630