Recent Developments in the Understanding of Immunity, Pathogenesis and Management of COVID-19
, Arbi Abnousian 1, Logan J. Alexander 1, Ali Badaoui 1, Brandon Flaig 1, Nisar Sheren 1, Armin Aghazarian 1, Dijla Alsaigh 1, Arman Amin 1, Akaash Mundra 1, Anthony Nazaryan 1, Frederick T. Guilford 2,* and Vishwanath Venketaraman 1,*
Round 1
Reviewer 1 Report
Competent, well written review.
Remarks:
The author could consider inserting a table documenting the decrease in GSH content in various viral diseases including the cells/tissues where the GSH level was quantified. It is a suggestion but not a requirement; the review is well balanced in the submitted form.
Fig. 1 Please explain D1, D2
Line 232: “was severely diminished”, wouldn’t “is severely diminished” be better?
Line 240: which isoenzyme of superoxide dismutase?
Lines 276-279: NADPH is required rather for GSH regeneration (from GSSG, by glutathione reductase) than GSH generation
Author Response
Cover letter: Recent Developments in the understanding of immunity, pathogenesis and management of COVID-19.
REVIEWER#1
Thank you for reviewing our paper and suggesting the edits stated below, we have looked at all the suggestions and made the necessary revisions as requested by reviewer 1 and 2.
The following comments/remarks:
The author could consider inserting a table documenting the decrease in GSH content in various viral diseases including the cells/tissues where the GSH level was quantified. It is a suggestion but not a requirement; the review is well balanced in the submitted form.
- Thank you for the suggestion it is a great point but we have decided to not include a table at the time.
Fig. 1 Please explain D1, D2
- Added parenthesis in the text to explain what they are in the figure.
Line 232: “was severely diminished”, wouldn’t “is severely diminished” be better?
- Changed “was” to “is”
Line 240: which isoenzyme of superoxide dismutase?
- Changed to Superoxide dismutase isoform 1 (SOD1) to be more specific
Lines 276-279: NADPH is required rather for GSH regeneration (from GSSG, by glutathione reductase) than GSH generation
- Changed to “plays a role in the regeneration of GSH”
Author Response File: 
Author Response.docx
Reviewer 2 Report
The authors presented a comprehensive review on the COVID-19. They touch the problem from various sides and consider its different aspects. The only thing I would add to this paper, is some more information about the latest mutations of the omicron variant and also on the changing symptoms/mortality with the subsequent dominating variants of the virus. I would also like to congratulate authors on their great work.
Author Response
Cover letter: Recent Developments in the understanding of immunity, pathogenesis and management of COVID-19.
Thank you for reviewing our paper and suggesting the edits stated below, we have looked at all the suggestions and made the necessary revisions as requested by reviewer 1 and 2.
REVIEWER#2
The authors presented a comprehensive review on the COVID-19. They touch the problem from various sides and consider its different aspects. The only thing I would add to this paper, is some more information about the latest mutations of the omicron variant and also on the changing symptoms/mortality with the subsequent dominating variants of the virus. I would also like to congratulate authors on their great work.
- Added to the paragraph in section 2.2 with further information on the omicron variant.
Author Response File: Author Response.docx
