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Volume 23
Issue 16
10.3390/ijms23169088
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Review
Peer-Review Record

Physiological and Pathological Functions of Neuronal Hemoglobin: A Key Underappreciated Protein in Parkinson’s Disease

Int. J. Mol. Sci. 2022, 23(16), 9088; https://doi.org/10.3390/ijms23169088
by Ran Zheng, Yiqun Yan, Jiali Pu * and Baorong Zhang *
Reviewer 1:
Thomas Müller
Reviewer 2:
José Luis Zugaza
Int. J. Mol. Sci. 2022, 23(16), 9088; https://doi.org/10.3390/ijms23169088
Submission received: 29 June 2022 / Revised: 9 August 2022 / Accepted: 11 August 2022 / Published: 13 August 2022
(This article belongs to the Special Issue Understanding Parkinson's Disease)

Round 1

Reviewer 1 Report

This review describes an association between mitochondrial dysfunction and hemoglobin and chronic neurodegeneration. It is potentially interesting. The authors may additionally discuss the impact of vitamin D and its impact of blood perfusion parameters due to its steroid like chemical structure in the context of this review. At the current stage this review only focus on the interaction of various well known causes and mechanisms of chronic neurodegeneration without reflections on possible influencing therapeutic options.     

Author Response

Dear reviewer 1，

We gratefully appreciate for your critical comments on our manuscript. Based on these comments, we have made careful modifications on the original manuscript and provided responses to each of the points.

Please see the attachment.

Yours sincerely,

Baorong Zhang

Author Response File: Author Response.pdf

Reviewer 2 Report

It is a very interesting review in which Zheng et al., recapitulate how neuronal hemoglobin contribute to neuropathological changes of Parkinson Disease. It is well organized, written and easy to follow, the references are up to date and it is of high interest to IJMS readers.

To make it easier for readers to understand the problem, I think that the authors should present in the introduction, in a general way, the neuropathological changes present in Parkinson's disease in order to later address the problem of HB. And on the other hand in point 8.4 authors should explain if the GH/IGF-I axis is really relevant in the Hb and PD relationship.

Author Response

Dear reviewer 2,

We gratefully appreciate for your thoughtful suggestions on our manuscript. Based on these suggestions, we have made careful modifications on the original manuscript and provided responses to each of the points.

Please see the attachment.

Yours sincerely,

Baorong Zhang

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

accpet now

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