Next Article in Journal
Highly Stretchable and Sensitive Flexible Strain Sensor Based on Fe NWs/Graphene/PEDOT:PSS with a Porous Structure
Next Article in Special Issue
Novel Triterpenic Acid—Benzotriazole Esters Act as Pro-Apoptotic Antimelanoma Agents
Previous Article in Journal
Hepatocyte Nuclear Factor 1α Proinflammatory Effect Linked to the Overexpression of Liver Nuclear Factor–κB in Experimental Model of Chronic Kidney Disease
Previous Article in Special Issue
Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I)
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 23
Issue 16
10.3390/ijms23168896
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part II)

by
Marius Mioc
1,2,†,
Alexandra Prodea
1,2,†,
Roxana Racoviceanu
1,2,*,
Alexandra Mioc
2,3,*,
Roxana Ghiulai
1,2,
Andreea Milan
1,2,
Mirela Voicu
2,4,
Gabriel Mardale
1,2 and
Codruța Șoica
1,2
1
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania
2
Research Centre for Pharmaco-Toxicological Evaluation, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq., No. 2, 300041 Timisoara, Romania
3
Department of Anatomy, Physiology, Pathophysiology, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq., No. 2, 300041 Timisoara, Romania
4
Department of Pharmacology-Pharmacotherapy, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2022, 23(16), 8896; https://doi.org/10.3390/ijms23168896
Submission received: 20 July 2022 / Revised: 4 August 2022 / Accepted: 8 August 2022 / Published: 10 August 2022
(This article belongs to the Special Issue Molecular Mechanisms Involved in the Chemopreventive and Anticancer Activity of Pentacyclic Triterpenes 2.0)
Browse Figures
Versions Notes

Abstract

Triterpenic acids are a widespread class of phytocompounds which have been found to possess valuable therapeutic properties such as anticancer, anti-inflammatory, hepatoprotective, cardioprotective, antidiabetic, neuroprotective, lipolytic, antiviral, and antiparasitic effects. They are a subclass of triterpenes bearing a characteristic lipophilic structure that imprints unfavorable in vivo properties which subsequently limit their applications. The early investigation of the mechanism of action (MOA) of a drug candidate can provide valuable information regarding the possible side effects and drug interactions that may occur after administration. The current paper aimed to summarize the most recent (last 5 years) studies regarding the MOA of betulinic acid, boswellic acid, glycyrrhetinic acid, madecassic acid, moronic acid, and pomolic acid in order to provide scientists with updated and accessible material on the topic that could contribute to the development of future studies; the paper stands as the sequel of our previously published paper regarding the MOA of triterpenic acids with therapeutic value. The recent literature published on the topic has highlighted the role of triterpenic acids in several signaling pathways including PI3/AKT/mTOR, TNF-alpha/NF-kappa B, JNK-p38, HIF-α/AMPK, and Grb2/Sos/Ras/MAPK, which trigger their various biological activities.
Keywords: molecular mechanism; triterpenic acids; apoptosis; betulinic acid; glycyrrhetinic acid; maslinic acid; boswellic acid; madecassic acid; pomolic acid; moronic acid; pentacyclic triterpenes molecular mechanism; triterpenic acids; apoptosis; betulinic acid; glycyrrhetinic acid; maslinic acid; boswellic acid; madecassic acid; pomolic acid; moronic acid; pentacyclic triterpenes

Share and Cite

MDPI and ACS Style

Mioc, M.; Prodea, A.; Racoviceanu, R.; Mioc, A.; Ghiulai, R.; Milan, A.; Voicu, M.; Mardale, G.; Șoica, C. Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part II). Int. J. Mol. Sci. 2022, 23, 8896. https://doi.org/10.3390/ijms23168896

AMA Style

Mioc M, Prodea A, Racoviceanu R, Mioc A, Ghiulai R, Milan A, Voicu M, Mardale G, Șoica C. Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part II). International Journal of Molecular Sciences. 2022; 23(16):8896. https://doi.org/10.3390/ijms23168896

Chicago/Turabian Style

Mioc, Marius, Alexandra Prodea, Roxana Racoviceanu, Alexandra Mioc, Roxana Ghiulai, Andreea Milan, Mirela Voicu, Gabriel Mardale, and Codruța Șoica. 2022. "Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part II)" International Journal of Molecular Sciences 23, no. 16: 8896. https://doi.org/10.3390/ijms23168896

APA Style

Mioc, M., Prodea, A., Racoviceanu, R., Mioc, A., Ghiulai, R., Milan, A., Voicu, M., Mardale, G., & Șoica, C. (2022). Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part II). International Journal of Molecular Sciences, 23(16), 8896. https://doi.org/10.3390/ijms23168896

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop