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Volume 23
Issue 15
10.3390/ijms23158165
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Review
Peer-Review Record

Hypoxia in Aging and Aging-Related Diseases: Mechanism and Therapeutic Strategies

Int. J. Mol. Sci. 2022, 23(15), 8165; https://doi.org/10.3390/ijms23158165
by Yaqin Wei 1, Sergio Giunta 2 and Shijin Xia 1,*
Reviewer 1: Anonymous
Int. J. Mol. Sci. 2022, 23(15), 8165; https://doi.org/10.3390/ijms23158165
Submission received: 26 June 2022 / Revised: 12 July 2022 / Accepted: 14 July 2022 / Published: 25 July 2022
(This article belongs to the Special Issue Aging: Oxidative Stress and Inflammation: New Target to Promote Healthy Longevity)

Round 1

Reviewer 1 Report

Wei et al., in their article "Hypoxia in Aging and Aging-Related Diseases: Mechanism and 2 Therapeutic Strategies," examine the function of different degrees and types of hypoxia in aging and aging-related disease pathways, and provide logical therapeutic alternatives based on such processes. The book is beautifully written and discusses hypoxia's function in aging. It covers all current features of hypoxia. The authors performed an outstanding job. There was only one minor issue:

 

1. The abbreviated form of tricarboxylic acid, TAC, should be changed to TCA on page 3 line 110.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

This review article sought to elucidate the role played by different degrees and types of hypoxia in aging and aging-related diseases and its possible pathways.  In this review, the authors summarized and discussed the effects of hypoxia and oxidative stress on physiological or biochemical activities, and review the potential link between the direct or indirect involvement of hypoxia in the aging process and the role of age-related diseases.  This manuscript is interesting, but I have some concerns that need to be addressed as follows:

Major concerns:

1.      A growing body of research has shown that mitophagy plays a pivotal role during aging.  Thus, the authors should provide more information about the effects of hypoxia on mitophagy in aging and aging-related diseases.  

 

2.      For the antioxidant and anti-aging based therapeutic perspectives, recent clinical trials have shown that hyperbaric oxygen therapy (HBOT) can target aging hallmarks, including telomere shortening and senescent cells clearance.  Thus, authors should also include the HBOT in this section.

Minor concerns:

1.      Page 7, Figure1, “Hypoxia” should be moved upward and placed at the same level as “Normoxia”.

 

2.      Page 7, Line 309, “iInvolved” should be “Involved”.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Round 2

Reviewer 2 Report

 

The authors have addressed my concerns, and I recommend publication in the journal.

 

 

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