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Article

A Novel Artificial Hemoglobin Carrier Based on Heulandite-Calcium Mesoporous Aluminosilicate Particles

by
Dino Jordanoski
1,
Damjana Drobne
1,
Neža Repar
1,
Iztok Dogsa
1,
Polona Mrak
1,
Romana Cerc-Korošec
2,
Andrijana Sever Škapin
3,
Peter Nadrah
3 and
Natasa Poklar Ulrih
1,*
1
Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, 1000 Ljubljana, Slovenia
2
Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna Pot, 1000 Ljubljana, Slovenia
3
Slovenian National Bulding and Civil Engineering Institute, Dimičeva Ulica 12, 1000 Ljubljana, Slovenia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(13), 7460; https://doi.org/10.3390/ijms23137460
Submission received: 2 June 2022 / Revised: 30 June 2022 / Accepted: 1 July 2022 / Published: 5 July 2022
(This article belongs to the Collection Feature Papers in Materials Science)
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Abstract

Tetraethyl-orthosilicate (TEOS)-based nanoparticles are most extensively used as a silica-based hemoglobin carrier system. However, TEOS-based nanoparticles induce adverse effects on the hemoglobin structure. Therefore, a heulandite-calcium-based carrier was investigated as a novel silica-based hemoglobin carrier system. The heulandite-calcium mesoporous aluminosilicate particles (MSPs) were fabricated by a patented tribo-mechanical activation process, according to the manufacturer, and its structure was assessed by X-ray diffraction analysis. Upon hemoglobin encapsulation, alternation in the secondary and tertiary structure was observed. The hemoglobin-particle interactions do not cause heme degradation or decreased activity. Once encapsulated inside the particle pores, the hemoglobin shows increased thermal stability, and higher loading capacity per gram of particles (by a factor of >1.4) when compared to TEOS-based nanoparticles. Futhermore, we introduced a PEGlyted lipid bilayer which significantly decreases the premature hemoglobin release and increases the colloidal stability. The newly developed hemoglobin carrier shows no cytotoxicity to human umbilical vein endothelial cells (HUVEC).
Keywords: silica particles; hemoglobin carrier; encapsulation; mesoporous; spectroscopy silica particles; hemoglobin carrier; encapsulation; mesoporous; spectroscopy

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MDPI and ACS Style

Jordanoski, D.; Drobne, D.; Repar, N.; Dogsa, I.; Mrak, P.; Cerc-Korošec, R.; Škapin, A.S.; Nadrah, P.; Poklar Ulrih, N. A Novel Artificial Hemoglobin Carrier Based on Heulandite-Calcium Mesoporous Aluminosilicate Particles. Int. J. Mol. Sci. 2022, 23, 7460. https://doi.org/10.3390/ijms23137460

AMA Style

Jordanoski D, Drobne D, Repar N, Dogsa I, Mrak P, Cerc-Korošec R, Škapin AS, Nadrah P, Poklar Ulrih N. A Novel Artificial Hemoglobin Carrier Based on Heulandite-Calcium Mesoporous Aluminosilicate Particles. International Journal of Molecular Sciences. 2022; 23(13):7460. https://doi.org/10.3390/ijms23137460

Chicago/Turabian Style

Jordanoski, Dino, Damjana Drobne, Neža Repar, Iztok Dogsa, Polona Mrak, Romana Cerc-Korošec, Andrijana Sever Škapin, Peter Nadrah, and Natasa Poklar Ulrih. 2022. "A Novel Artificial Hemoglobin Carrier Based on Heulandite-Calcium Mesoporous Aluminosilicate Particles" International Journal of Molecular Sciences 23, no. 13: 7460. https://doi.org/10.3390/ijms23137460

APA Style

Jordanoski, D., Drobne, D., Repar, N., Dogsa, I., Mrak, P., Cerc-Korošec, R., Škapin, A. S., Nadrah, P., & Poklar Ulrih, N. (2022). A Novel Artificial Hemoglobin Carrier Based on Heulandite-Calcium Mesoporous Aluminosilicate Particles. International Journal of Molecular Sciences, 23(13), 7460. https://doi.org/10.3390/ijms23137460

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