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Role of Impaired Mitochondrial Dynamics Processes in the Pathogenesis of Alzheimer’s Disease

1
Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 8 Baltiiskaya Street, 125315 Moscow, Russia
2
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 14-3 Solyanka Street, 109240 Moscow, Russia
3
Petrovsky National Research Centre of Surgery, AP Avtsyn Institute of Human Morphology, 117418 Moscow, Russia
*
Authors to whom correspondence should be addressed.
Academic Editor: Leo Veenman
Int. J. Mol. Sci. 2022, 23(13), 6954; https://doi.org/10.3390/ijms23136954
Received: 20 May 2022 / Revised: 17 June 2022 / Accepted: 21 June 2022 / Published: 23 June 2022
(This article belongs to the Special Issue The Molecular Brain and Its Health)
Mitochondrial dysfunction is now recognized as a contributing factor to neurodegenerative diseases, including Alzheimer’s disease (AD). Mitochondria are signaling organelles with a variety of functions ranging from energy production to the regulation of cellular metabolism, energy homeostasis, and response to stress. The successful functioning of these complex processes is critically dependent on the accuracy of mitochondrial dynamics, which includes the ability of mitochondria to change shape and position in the cell, which is necessary to maintain proper function and quality control, especially in polarized cells such as neurons. There has been much evidence to suggest that the disruption of mitochondrial dynamics may play a critical role in the pathogenesis of AD. This review highlights aspects of altered mitochondrial dynamics in AD that may contribute to the etiology of this debilitating condition. We also discuss therapeutic strategies to improve mitochondrial dynamics and function that may provide an alternative treatment approach. View Full-Text
Keywords: Alzheimer’s disease; neurons; mitochondrial dynamics Alzheimer’s disease; neurons; mitochondrial dynamics
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MDPI and ACS Style

Blagov, A.V.; Grechko, A.V.; Nikiforov, N.G.; Borisov, E.E.; Sadykhov, N.K.; Orekhov, A.N. Role of Impaired Mitochondrial Dynamics Processes in the Pathogenesis of Alzheimer’s Disease. Int. J. Mol. Sci. 2022, 23, 6954. https://doi.org/10.3390/ijms23136954

AMA Style

Blagov AV, Grechko AV, Nikiforov NG, Borisov EE, Sadykhov NK, Orekhov AN. Role of Impaired Mitochondrial Dynamics Processes in the Pathogenesis of Alzheimer’s Disease. International Journal of Molecular Sciences. 2022; 23(13):6954. https://doi.org/10.3390/ijms23136954

Chicago/Turabian Style

Blagov, Alexander V., Andrey V. Grechko, Nikita G. Nikiforov, Evgeny E. Borisov, Nikolay K. Sadykhov, and Alexander N. Orekhov. 2022. "Role of Impaired Mitochondrial Dynamics Processes in the Pathogenesis of Alzheimer’s Disease" International Journal of Molecular Sciences 23, no. 13: 6954. https://doi.org/10.3390/ijms23136954

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