Red Upconverter Nanocrystals Functionalized with Verteporfin for Photodynamic Therapy Triggered by Upconversion
Abstract
:1. Introduction
2. Results
Synthesis and Characterization of Pristine ZrO2 Nanocrystals Co-Doped with Er3+ and Yb3+ Ions
3. Discussion
4. Conclusions
5. Materials and Methods
5.1. Synthesis of Er3+/Yb3+ Doped ZrO2 Nanocrystals
5.2. Coating of Er0.005Yb0.02ZrO2 with Amino-Modified Amorphous Silica
5.3. Immobilization of Verteporfin on Silica Coated ZEY2 Nanoparticles
5.4. Characterization Methodologies
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Acronyms | Sample Composition | Sample Description |
---|---|---|
ZEY2 | Er0.005Yb0.02Zr1-(0.025)O2 | ZrO2 doped with Er3+ (0.5%) and Yb3+ (2%) |
ZEY5 | Er0.005Yb0.05Zr1-(0.055)O2 | ZrO2 doped with Er3+ (0.5%) and Yb3+ (5%) |
ZEY10 | Er0.005Yb0.1Zr1-(0.105)O2 | ZrO2 doped with Er3+ (0.5%) and Yb3+ (10%) |
ZEY2@SiO2 | Er0.005Yb0.02Zr1-(0.025)O2 | Silica-coated ZEY2 |
ZEY2-Ver | Er0.005Yb0.02Zr1-(0.025)O2 | Ver-modified ZEY2@SiO2 |
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Miletto, I.; Gionco, C.; Paganini, M.C.; Cerrato, E.; Marchese, L.; Gianotti, E. Red Upconverter Nanocrystals Functionalized with Verteporfin for Photodynamic Therapy Triggered by Upconversion. Int. J. Mol. Sci. 2022, 23, 6951. https://doi.org/10.3390/ijms23136951
Miletto I, Gionco C, Paganini MC, Cerrato E, Marchese L, Gianotti E. Red Upconverter Nanocrystals Functionalized with Verteporfin for Photodynamic Therapy Triggered by Upconversion. International Journal of Molecular Sciences. 2022; 23(13):6951. https://doi.org/10.3390/ijms23136951
Chicago/Turabian StyleMiletto, Ivana, Chiara Gionco, Maria Cristina Paganini, Erik Cerrato, Leonardo Marchese, and Enrica Gianotti. 2022. "Red Upconverter Nanocrystals Functionalized with Verteporfin for Photodynamic Therapy Triggered by Upconversion" International Journal of Molecular Sciences 23, no. 13: 6951. https://doi.org/10.3390/ijms23136951