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Review

Obesity and the Brain

1
Department of Environmental Medicine, Poznan University of Medical Sciences, Fredry 10, 61-701 Poznan, Poland
2
Department of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, Fredry 10, 61-701 Poznan, Poland
3
Institute of Human Genetics, Polish Academy of Science, Strzeszynska 32, 60-479 Poznan, Poland
4
Hypertension Angiology and Internal Medicine, Poznan University of Medical Sciences, Fredry 10, 61-701 Poznan, Poland
5
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, No. 228, 4050-313 Porto, Portugal
6
REQUIMTE/UCIBIO, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, No. 228, 4050-313 Porto, Portugal
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Giuseppe Esposito
Int. J. Mol. Sci. 2022, 23(11), 6145; https://doi.org/10.3390/ijms23116145
Received: 20 December 2021 / Revised: 26 May 2022 / Accepted: 26 May 2022 / Published: 30 May 2022
(This article belongs to the Collection State-of-the-Art Molecular Microbiology in Poland)
Innate and adaptive immunity are essential for neurodevelopment and central nervous system (CNS) homeostasis; however, the fragile equilibrium between immune and brain cells can be disturbed by any immune dysregulation and cause detrimental effects. Accumulating evidence indicates that, despite the blood–brain barrier (BBB), overactivation of the immune system leads to brain vulnerability that increases the risk of neuropsychiatric disorders, particularly upon subsequent exposure later in life. Disruption of microglial function in later life can be triggered by various environmental and psychological factors, including obesity-driven chronic low-grade inflammation and gut dysbiosis. Increased visceral adiposity has been recognized as an important risk factor for multiple neuropsychiatric conditions. The review aims to present our current understanding of the topic. View Full-Text
Keywords: obesity; neuropsychiatric diseases; neuroinflammation; microbiota; dysbiosis obesity; neuropsychiatric diseases; neuroinflammation; microbiota; dysbiosis
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MDPI and ACS Style

Karczewski, J.; Zielińska, A.; Staszewski, R.; Eder, P.; Dobrowolska, A.; Souto, E.B. Obesity and the Brain. Int. J. Mol. Sci. 2022, 23, 6145. https://doi.org/10.3390/ijms23116145

AMA Style

Karczewski J, Zielińska A, Staszewski R, Eder P, Dobrowolska A, Souto EB. Obesity and the Brain. International Journal of Molecular Sciences. 2022; 23(11):6145. https://doi.org/10.3390/ijms23116145

Chicago/Turabian Style

Karczewski, Jacek, Aleksandra Zielińska, Rafał Staszewski, Piotr Eder, Agnieszka Dobrowolska, and Eliana B. Souto. 2022. "Obesity and the Brain" International Journal of Molecular Sciences 23, no. 11: 6145. https://doi.org/10.3390/ijms23116145

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