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Article

Investigation of Chemical Constituents of Eranthis longistipitata (Ranunculaceae): Coumarins and Furochromones

1
Central Siberian Botanical Garden, Siberian Branch of Russian Academy of Sciences, CSBG SB RUS, 630090 Novosibirsk, Russia
2
Laboratory Herbarium (TK), Tomsk State University, 634050 Tomsk, Russia
3
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, ICBFM SB RAS, 630090 Novosibirsk, Russia
4
Komarov Botanical Institute, Russian Academy of Sciences, BIN RAS, 197376 St. Petersburg, Russia
5
K.A. Timiryazev Institute of Plant Physiology RAS, IPP RAS, 127276 Moscow, Russia
6
Institute of Botany, Chinese Academy of Sciences, IB CAS, Beijing 100093, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Jin Boo Jeong
Int. J. Mol. Sci. 2022, 23(1), 406; https://doi.org/10.3390/ijms23010406
Received: 17 December 2021 / Revised: 28 December 2021 / Accepted: 29 December 2021 / Published: 30 December 2021
Aqueous-ethanol extracts (70%) from the leaves of Eranthis longistipitata Regel. (Ranunculaceae Juss.)—collected from natural populations of Kyrgyzstan—were studied by liquid chromatography with high-resolution mass spectrometry (LC-HRMS). There was no variation of the metabolic profiles among plants that were collected from different populations. More than 160 compounds were found in the leaves, of which 72 were identified to the class level and 58 to the individual-compound level. The class of flavonoids proved to be the most widely represented (19 compounds), including six aglycones [quercetin, kaempferol, aromadendrin, 6-methoxytaxifolin, phloretin, and (+)-catechin] and mono- and diglycosides (the other 13 compounds). In the analyzed samples of E. longistipitata, 14 fatty acid–related compounds were identified, but coumarins and furochromones that were found in E. longistipitata were the most interesting result; furochromones khelloside, khellin, visnagin, and cimifugin were found in E. longistipitata for the first time. Coumarins 5,7-dihydroxy-4-methylcoumarin, scoparone, fraxetin, and luvangetin and furochromones methoxsalen, 5-O-methylvisammioside, and visamminol-3′-O-glucoside were detected for the first time in the genus Eranthis Salisb. For all the above compounds, the structural formulas are given. Furthermore, detailed information (with structural formulas) is provided on the diversity of chromones and furochromones in other representatives of Eranthis. The presence of chromones in plants of the genus Eranthis confirms its closeness to the genus Actaea L. because chromones are synthesized by normal physiological processes only in these members of the Ranunculaceae family. View Full-Text
Keywords: Ranunculaceae; Eranthis longistipitata; LC-HRMS; chemical composition; coumarin; furochromone; fatty acid; extract Ranunculaceae; Eranthis longistipitata; LC-HRMS; chemical composition; coumarin; furochromone; fatty acid; extract
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MDPI and ACS Style

Erst, A.S.; Chernonosov, A.A.; Petrova, N.V.; Kulikovskiy, M.S.; Maltseva, S.Y.; Wang, W.; Kostikova, V.A. Investigation of Chemical Constituents of Eranthis longistipitata (Ranunculaceae): Coumarins and Furochromones. Int. J. Mol. Sci. 2022, 23, 406. https://doi.org/10.3390/ijms23010406

AMA Style

Erst AS, Chernonosov AA, Petrova NV, Kulikovskiy MS, Maltseva SY, Wang W, Kostikova VA. Investigation of Chemical Constituents of Eranthis longistipitata (Ranunculaceae): Coumarins and Furochromones. International Journal of Molecular Sciences. 2022; 23(1):406. https://doi.org/10.3390/ijms23010406

Chicago/Turabian Style

Erst, Andrey S., Alexander A. Chernonosov, Natalia V. Petrova, Maxim S. Kulikovskiy, Svetlana Y. Maltseva, Wei Wang, and Vera A. Kostikova. 2022. "Investigation of Chemical Constituents of Eranthis longistipitata (Ranunculaceae): Coumarins and Furochromones" International Journal of Molecular Sciences 23, no. 1: 406. https://doi.org/10.3390/ijms23010406

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