Cholinergic Modulation of Neuroinflammation: Focus on α7 Nicotinic Receptor
Abstract
:1. Introduction
2. α7 nAChR Subtype
- -
- high permeability to calcium;
- -
- rapid activation and desensitization phase (in the order of milliseconds);
- -
- selective inhibition given by α-bungarotoxin (α-BTX) and methyllycaconitine (MLA), and a low affinity for nicotine.
3. α7 Metabotropic Signalling Mediates the Cholinergic Anti-Inflammatory Pathway
4. α7 nAChR Effects in the Glial Cells
5. Role of α7 nAChR in the Control of Neuroinflammation in the CNS Pathologies
6. α7 nAChR Neuropharmacology
7. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Nicotinic Agonists | Receptor Selectivity | Ki |
---|---|---|
SEN 12333 | Full agonist α7 subunit | 260 nM |
PNU-282907 | Full agonist α7 subunit | 27 nM |
PNU-120596 | Full agonist α7 subunit | 0.9 µM |
TC 5619 | Full agonist α7 subunit | 1 nM |
ICH3 | Partial agonist α7 subunit | 4.6 nM |
S24795 | Partial agonist α7 subunit | 34 nM |
A-582941 | Partial agonist α7 subunit | 16 nM |
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Piovesana, R.; Salazar Intriago, M.S.; Dini, L.; Tata, A.M. Cholinergic Modulation of Neuroinflammation: Focus on α7 Nicotinic Receptor. Int. J. Mol. Sci. 2021, 22, 4912. https://doi.org/10.3390/ijms22094912
Piovesana R, Salazar Intriago MS, Dini L, Tata AM. Cholinergic Modulation of Neuroinflammation: Focus on α7 Nicotinic Receptor. International Journal of Molecular Sciences. 2021; 22(9):4912. https://doi.org/10.3390/ijms22094912
Chicago/Turabian StylePiovesana, Roberta, Michael Sebastian Salazar Intriago, Luciana Dini, and Ada Maria Tata. 2021. "Cholinergic Modulation of Neuroinflammation: Focus on α7 Nicotinic Receptor" International Journal of Molecular Sciences 22, no. 9: 4912. https://doi.org/10.3390/ijms22094912