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Review

Gut Susceptibility to Viral Invasion: Contributing Roles of Diet, Microbiota and Enteric Nervous System to Mucosal Barrier Preservation

1
Grupo de NeuroGastroBioquímica, Instituto de Química, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, Valparaíso 2340000, Chile
2
APC Microbiome Ireland, University College Cork, T12 K8AF Cork, Ireland
3
Centro de Micro-Bioinnovación (CMBi), Escuela de Nutrición y Dietética, Facultad de Farmacia, Universidad de Valparaíso, Valparaíso 2340000, Chile
4
Centro de Neurobiología y Fisiopatología Integrativa (CENFI), Instituto de Fisiología, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2340000, Chile
*
Author to whom correspondence should be addressed.
Academic Editor: Silvia Melgar
Int. J. Mol. Sci. 2021, 22(9), 4734; https://doi.org/10.3390/ijms22094734
Received: 28 March 2021 / Revised: 24 April 2021 / Accepted: 26 April 2021 / Published: 29 April 2021
The gastrointestinal lumen is a rich source of eukaryotic and prokaryotic viruses which, together with bacteria, fungi and other microorganisms comprise the gut microbiota. Pathogenic viruses inhabiting this niche have the potential to induce local as well as systemic complications; among them, the viral ability to disrupt the mucosal barrier is one mechanism associated with the promotion of diarrhea and tissue invasion. This review gathers recent evidence showing the contributing effects of diet, gut microbiota and the enteric nervous system to either support or impair the mucosal barrier in the context of viral attack. View Full-Text
Keywords: gut; permeability; barrier; epithelium; submucosal neurons; gastrointestinal disorders gut; permeability; barrier; epithelium; submucosal neurons; gastrointestinal disorders
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MDPI and ACS Style

Julio-Pieper, M.; López-Aguilera, A.; Eyzaguirre-Velásquez, J.; Olavarría-Ramírez, L.; Ibacache-Quiroga, C.; Bravo, J.A.; Cruz, G. Gut Susceptibility to Viral Invasion: Contributing Roles of Diet, Microbiota and Enteric Nervous System to Mucosal Barrier Preservation. Int. J. Mol. Sci. 2021, 22, 4734. https://doi.org/10.3390/ijms22094734

AMA Style

Julio-Pieper M, López-Aguilera A, Eyzaguirre-Velásquez J, Olavarría-Ramírez L, Ibacache-Quiroga C, Bravo JA, Cruz G. Gut Susceptibility to Viral Invasion: Contributing Roles of Diet, Microbiota and Enteric Nervous System to Mucosal Barrier Preservation. International Journal of Molecular Sciences. 2021; 22(9):4734. https://doi.org/10.3390/ijms22094734

Chicago/Turabian Style

Julio-Pieper, Marcela, Alejandra López-Aguilera, Johana Eyzaguirre-Velásquez, Loreto Olavarría-Ramírez, Claudia Ibacache-Quiroga, Javier A. Bravo, and Gonzalo Cruz. 2021. "Gut Susceptibility to Viral Invasion: Contributing Roles of Diet, Microbiota and Enteric Nervous System to Mucosal Barrier Preservation" International Journal of Molecular Sciences 22, no. 9: 4734. https://doi.org/10.3390/ijms22094734

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