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The Multifaceted Roles of USP15 in Signal Transduction

Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02793, Korea
Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, Korea
Authors to whom correspondence should be addressed.
Academic Editor: Kwang-Hyun Baek
Int. J. Mol. Sci. 2021, 22(9), 4728;
Received: 31 March 2021 / Revised: 26 April 2021 / Accepted: 26 April 2021 / Published: 29 April 2021
Ubiquitination and deubiquitination are protein post-translational modification processes that have been recognized as crucial mediators of many complex cellular networks, including maintaining ubiquitin homeostasis, controlling protein stability, and regulating several signaling pathways. Therefore, some of the enzymes involved in ubiquitination and deubiquitination, particularly E3 ligases and deubiquitinases, have attracted attention for drug discovery. Here, we review recent findings on USP15, one of the deubiquitinases, which regulates diverse signaling pathways by deubiquitinating vital target proteins. Even though several basic previous studies have uncovered the versatile roles of USP15 in different signaling networks, those have not yet been systematically and specifically reviewed, which can provide important information about possible disease markers and clinical applications. This review will provide a comprehensive overview of our current understanding of the regulatory mechanisms of USP15 on different signaling pathways for which dynamic reverse ubiquitination is a key regulator. View Full-Text
Keywords: USP15; TGF-β; BMP; NF-κB; Wnt/β-catenin; CSN; p53; IGF; Nrf2–Keap1; RNA splicing USP15; TGF-β; BMP; NF-κB; Wnt/β-catenin; CSN; p53; IGF; Nrf2–Keap1; RNA splicing
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MDPI and ACS Style

Das, T.; Song, E.J.; Kim, E.E. The Multifaceted Roles of USP15 in Signal Transduction. Int. J. Mol. Sci. 2021, 22, 4728.

AMA Style

Das T, Song EJ, Kim EE. The Multifaceted Roles of USP15 in Signal Transduction. International Journal of Molecular Sciences. 2021; 22(9):4728.

Chicago/Turabian Style

Das, Tanuza, Eun Joo Song, and Eunice EunKyeong Kim. 2021. "The Multifaceted Roles of USP15 in Signal Transduction" International Journal of Molecular Sciences 22, no. 9: 4728.

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