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Cannabidiol and Other Cannabinoids in Demyelinating Diseases
Review

Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action

1
Department of Biotechnology, Institute of Natural Fibres and Medicinal Plants—State Research Institute, Wojska Polskiego 71B, 60-630 Poznań, Poland
2
Chair and Department of Medical Microbiology, Poznań University of Medical Sciences, Wieniawskiego 3, 61-712 Poznań, Poland
3
Institute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, Poland
4
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal
5
CEB—Center of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal
*
Author to whom correspondence should be addressed.
Academic Editor: Philippe De Deurwaerdère
Int. J. Mol. Sci. 2021, 22(9), 4294; https://doi.org/10.3390/ijms22094294
Received: 24 March 2021 / Revised: 17 April 2021 / Accepted: 19 April 2021 / Published: 21 April 2021
As the major nonpsychotropic constituent of Cannabis sativa, cannabidiol (CBD) is regarded as one of the most promising therapeutic agents due to its proven effectiveness in clinical trials for many human diseases. Due to the urgent need for more efficient pharmacological treatments for several chronic diseases, in this review, we discuss the potential beneficial effects of CBD for Alzheimer’s disease, epilepsy, multiple sclerosis, and neurological cancers. Due to its wide range of pharmacological activities (e.g., antioxidant, anti-inflammatory, and neuroprotective properties), CBD is considered a multimodal drug for the treatment of a range of neurodegenerative disorders, and various cancer types, including neoplasms of the neural system. The different mechanisms of action of CBD are here disclosed, together with recent progress in the use of this cannabis-derived constituent as a new therapeutic approach. View Full-Text
Keywords: Cannabis sativa; cannabidiol; CBD; mechanism of action; Alzheimer’s disease; epilepsy; multiple sclerosis; cancer; pharmacological activity Cannabis sativa; cannabidiol; CBD; mechanism of action; Alzheimer’s disease; epilepsy; multiple sclerosis; cancer; pharmacological activity
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MDPI and ACS Style

Ożarowski, M.; Karpiński, T.M.; Zielińska, A.; Souto, E.B.; Wielgus, K. Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action. Int. J. Mol. Sci. 2021, 22, 4294. https://doi.org/10.3390/ijms22094294

AMA Style

Ożarowski M, Karpiński TM, Zielińska A, Souto EB, Wielgus K. Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action. International Journal of Molecular Sciences. 2021; 22(9):4294. https://doi.org/10.3390/ijms22094294

Chicago/Turabian Style

Ożarowski, Marcin; Karpiński, Tomasz M.; Zielińska, Aleksandra; Souto, Eliana B.; Wielgus, Karolina. 2021. "Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action" Int. J. Mol. Sci. 22, no. 9: 4294. https://doi.org/10.3390/ijms22094294

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