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Article

The Affinity of Carboplatin to B-Vitamins and Nucleobases

Department of Physical Chemistry, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Kurpińskiego 5, 85-096 Bydgoszcz, Poland
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Author to whom correspondence should be addressed.
Academic Editor: Antonello Merlino
Int. J. Mol. Sci. 2021, 22(7), 3634; https://doi.org/10.3390/ijms22073634
Received: 18 March 2021 / Revised: 26 March 2021 / Accepted: 28 March 2021 / Published: 31 March 2021
Platinum compounds have found wide application in the treatment of various types of cancer and carboplatin is one of the main platinum-based drugs used as antitumor agents. The anticancer activity of carboplatin arises from interacting with DNA and inducing programmed cell death. However, such interactions may occur with other chemical compounds, such as vitamins containing aromatic rings with lone-pair orbitals, which reduces the anti-cancer effect of carboplatin. The most important aspect of the conducted research was related to the evaluation of carboplatin affinity to vitamins from the B group and the potential impact of such interactions on the reduction of therapeutic capabilities of carboplatin in anticancer therapy. Realized computations, including estimation of Gibbs Free Energies, allowed for the identification of the most reactive molecule, namely vitamin B6 (pyridoxal phosphate). In this case, the computational estimations indicating carboplatin reactivity were confirmed by spectrophotometric measurements. View Full-Text
Keywords: carboplatin; lung cancer; cancer treatment; vitamin B; thiamine; riboflavin; niacin; pyridoxal phosphate; adenine; guanine carboplatin; lung cancer; cancer treatment; vitamin B; thiamine; riboflavin; niacin; pyridoxal phosphate; adenine; guanine
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MDPI and ACS Style

Szefler, B.; Czeleń, P.; Krawczyk, P. The Affinity of Carboplatin to B-Vitamins and Nucleobases. Int. J. Mol. Sci. 2021, 22, 3634. https://doi.org/10.3390/ijms22073634

AMA Style

Szefler B, Czeleń P, Krawczyk P. The Affinity of Carboplatin to B-Vitamins and Nucleobases. International Journal of Molecular Sciences. 2021; 22(7):3634. https://doi.org/10.3390/ijms22073634

Chicago/Turabian Style

Szefler, Beata, Przemysław Czeleń, and Przemysław Krawczyk. 2021. "The Affinity of Carboplatin to B-Vitamins and Nucleobases" International Journal of Molecular Sciences 22, no. 7: 3634. https://doi.org/10.3390/ijms22073634

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