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An Update on Connexin Gap Junction and Hemichannels in Diabetic Retinopathy

Mechanisms Underlying Connexin Hemichannel Activation in Disease

Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
Department of Medical Imaging, In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Lih Kuo
Int. J. Mol. Sci. 2021, 22(7), 3503;
Received: 15 March 2021 / Revised: 22 March 2021 / Accepted: 26 March 2021 / Published: 28 March 2021
(This article belongs to the Special Issue Connexin and Pannexin Signaling in Health and Disease)
Gap junctions and connexin hemichannels mediate intercellular and extracellular communication, respectively. While gap junctions are seen as the “good guys” by controlling homeostasis, connexin hemichannels are considered as the “bad guys”, as their activation is associated with the onset and dissemination of disease. Open connexin hemichannels indeed mediate the transport of messengers between the cytosol and extracellular environment and, by doing so, fuel inflammation and cell death in a plethora of diseases. The present mini-review discusses the mechanisms involved in the activation of connexin hemichannels during pathology. View Full-Text
Keywords: connexin hemichannel; pathology; mechanism connexin hemichannel; pathology; mechanism
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MDPI and ACS Style

Van Campenhout, R.; Gomes, A.R.; De Groof, T.W.M.; Muyldermans, S.; Devoogdt, N.; Vinken, M. Mechanisms Underlying Connexin Hemichannel Activation in Disease. Int. J. Mol. Sci. 2021, 22, 3503.

AMA Style

Van Campenhout R, Gomes AR, De Groof TWM, Muyldermans S, Devoogdt N, Vinken M. Mechanisms Underlying Connexin Hemichannel Activation in Disease. International Journal of Molecular Sciences. 2021; 22(7):3503.

Chicago/Turabian Style

Van Campenhout, Raf, Ana R. Gomes, Timo W.M. De Groof, Serge Muyldermans, Nick Devoogdt, and Mathieu Vinken. 2021. "Mechanisms Underlying Connexin Hemichannel Activation in Disease" International Journal of Molecular Sciences 22, no. 7: 3503.

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