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Review

The Role of CXCL16 in the Pathogenesis of Cancer and Other Diseases

1
Department of Biochemistry and Medical Chemistry, Powstańców Wielkopolskich 72 Av., Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland
2
Department of Medical Genetics, School of Medicine in Katowice, Medical University of Silesia, Medyków 18, 40-752 Katowice, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Sherine F. Elsawa
Int. J. Mol. Sci. 2021, 22(7), 3490; https://doi.org/10.3390/ijms22073490
Received: 2 February 2021 / Revised: 23 March 2021 / Accepted: 26 March 2021 / Published: 28 March 2021
(This article belongs to the Special Issue The Role of the Tumor Microenvironment in Cancer)
CXCL16 is a chemotactic cytokine belonging to the α-chemokine subfamily. It plays a significant role in the progression of cancer, as well as the course of atherosclerosis, renal fibrosis, and non-alcoholic fatty liver disease (NAFLD). Since there has been no review paper discussing the importance of this chemokine in various diseases, we have collected all available knowledge about CXCL16 in this review. In the first part of the paper, we discuss background information about CXCL16 and its receptor, CXCR6. Next, we focus on the importance of CXCL16 in a variety of diseases, with an emphasis on cancer. We discuss the role of CXCL16 in tumor cell proliferation, migration, invasion, and metastasis. Next, we describe the role of CXCL16 in the tumor microenvironment, including involvement in angiogenesis, and its significance in tumor-associated cells (cancer associated fibroblasts (CAF), microglia, tumor-associated macrophages (TAM), tumor-associated neutrophils (TAN), mesenchymal stem cells (MSC), myeloid suppressor cells (MDSC), and regulatory T cells (Treg)). Finally, we focus on the antitumor properties of CXCL16, which are mainly caused by natural killer T (NKT) cells. At the end of the article, we summarize the importance of CXCL16 in cancer therapy. View Full-Text
Keywords: CXCL16; CXCR6; cancer; tumor; NKT cells; SR-PSOX; ADAM10; tumor microenvironment; inflammation CXCL16; CXCR6; cancer; tumor; NKT cells; SR-PSOX; ADAM10; tumor microenvironment; inflammation
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MDPI and ACS Style

Korbecki, J.; Bajdak-Rusinek, K.; Kupnicka, P.; Kapczuk, P.; Simińska, D.; Chlubek, D.; Baranowska-Bosiacka, I. The Role of CXCL16 in the Pathogenesis of Cancer and Other Diseases. Int. J. Mol. Sci. 2021, 22, 3490. https://doi.org/10.3390/ijms22073490

AMA Style

Korbecki J, Bajdak-Rusinek K, Kupnicka P, Kapczuk P, Simińska D, Chlubek D, Baranowska-Bosiacka I. The Role of CXCL16 in the Pathogenesis of Cancer and Other Diseases. International Journal of Molecular Sciences. 2021; 22(7):3490. https://doi.org/10.3390/ijms22073490

Chicago/Turabian Style

Korbecki, Jan, Karolina Bajdak-Rusinek, Patrycja Kupnicka, Patrycja Kapczuk, Donata Simińska, Dariusz Chlubek, and Irena Baranowska-Bosiacka. 2021. "The Role of CXCL16 in the Pathogenesis of Cancer and Other Diseases" International Journal of Molecular Sciences 22, no. 7: 3490. https://doi.org/10.3390/ijms22073490

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