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Article

The Multifunctional Sactipeptide Ruminococcin C1 Displays Potent Antibacterial Activity In Vivo as Well as Other Beneficial Properties for Human Health

by
Clarisse Roblin
1,2,
Steve Chiumento
3,
Cédric Jacqueline
4,
Eric Pinloche
2,
Cendrine Nicoletti
1,
Hamza Olleik
1,
Elise Courvoisier-Dezord
1,
Agnès Amouric
1,
Christian Basset
3,
Louis Dru
1,3,
Marie Ollivier
5,
Aurélie Bogey-Lambert
5,
Nicolas Vidal
6,
Mohamed Atta
3,
Marc Maresca
1,
Estelle Devillard
2,
Victor Duarte
3,
Josette Perrier
1 and
Mickael Lafond
1,*
1
CNRS, Aix-Marseille University, Centrale Marseille, iSm2, 13013 Marseille, France
2
Centre d’Expertise et de Recherche en Nutrition, ADISSEO France SAS, 03600 Commentry, France
3
University Grenoble Alpes, CEA, IRIG, CBM, CNRS UMR5249, 38054 Grenoble, France
4
EA3826, IRS2 Nantes-Biotech, Université de Nantes, 44200 Nantes, France
5
BioAzur Biogroup-Vet’Analys Laboratory, 83400 Hyères, France
6
Yelen Analytics, Aix-Marseille University ICR, 13013 Marseille, France
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(6), 3253; https://doi.org/10.3390/ijms22063253
Submission received: 23 February 2021 / Revised: 11 March 2021 / Accepted: 18 March 2021 / Published: 23 March 2021
(This article belongs to the Special Issue Antimicrobial Peptides and Antimicrobial Chemokines)
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Abstract

The world is on the verge of a major antibiotic crisis as the emergence of resistant bacteria is increasing, and very few novel molecules have been discovered since the 1960s. In this context, scientists have been exploring alternatives to conventional antibiotics, such as ribosomally synthesized and post-translationally modified peptides (RiPPs). Interestingly, the highly potent in vitro antibacterial activity and safety of ruminococcin C1, a recently discovered RiPP belonging to the sactipeptide subclass, has been demonstrated. The present results show that ruminococcin C1 is efficient at curing infection and at protecting challenged mice from Clostridium perfringens with a lower dose than the conventional antibiotic vancomycin. Moreover, antimicrobial peptide (AMP) is also effective against this pathogen in the complex microbial community of the gut environment, with a selective impact on a few bacterial genera, while maintaining a global homeostasis of the microbiome. In addition, ruminococcin C1 exhibits other biological activities that could be beneficial for human health, as well as other fields of applications. Overall, this study, by using an in vivo infection approach, confirms the antimicrobial clinical potential and highlights the multiple functional properties of ruminococcin C1, thus extending its therapeutic interest.
Keywords: antibiotics; antimicrobial resistance; RiPP; sactipeptide; Ruminococcus gnavus E1; peritonitis infection; microbiome; Clostridium perfringens antibiotics; antimicrobial resistance; RiPP; sactipeptide; Ruminococcus gnavus E1; peritonitis infection; microbiome; Clostridium perfringens

Share and Cite

MDPI and ACS Style

Roblin, C.; Chiumento, S.; Jacqueline, C.; Pinloche, E.; Nicoletti, C.; Olleik, H.; Courvoisier-Dezord, E.; Amouric, A.; Basset, C.; Dru, L.; et al. The Multifunctional Sactipeptide Ruminococcin C1 Displays Potent Antibacterial Activity In Vivo as Well as Other Beneficial Properties for Human Health. Int. J. Mol. Sci. 2021, 22, 3253. https://doi.org/10.3390/ijms22063253

AMA Style

Roblin C, Chiumento S, Jacqueline C, Pinloche E, Nicoletti C, Olleik H, Courvoisier-Dezord E, Amouric A, Basset C, Dru L, et al. The Multifunctional Sactipeptide Ruminococcin C1 Displays Potent Antibacterial Activity In Vivo as Well as Other Beneficial Properties for Human Health. International Journal of Molecular Sciences. 2021; 22(6):3253. https://doi.org/10.3390/ijms22063253

Chicago/Turabian Style

Roblin, Clarisse, Steve Chiumento, Cédric Jacqueline, Eric Pinloche, Cendrine Nicoletti, Hamza Olleik, Elise Courvoisier-Dezord, Agnès Amouric, Christian Basset, Louis Dru, and et al. 2021. "The Multifunctional Sactipeptide Ruminococcin C1 Displays Potent Antibacterial Activity In Vivo as Well as Other Beneficial Properties for Human Health" International Journal of Molecular Sciences 22, no. 6: 3253. https://doi.org/10.3390/ijms22063253

APA Style

Roblin, C., Chiumento, S., Jacqueline, C., Pinloche, E., Nicoletti, C., Olleik, H., Courvoisier-Dezord, E., Amouric, A., Basset, C., Dru, L., Ollivier, M., Bogey-Lambert, A., Vidal, N., Atta, M., Maresca, M., Devillard, E., Duarte, V., Perrier, J., & Lafond, M. (2021). The Multifunctional Sactipeptide Ruminococcin C1 Displays Potent Antibacterial Activity In Vivo as Well as Other Beneficial Properties for Human Health. International Journal of Molecular Sciences, 22(6), 3253. https://doi.org/10.3390/ijms22063253

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