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Local Protein Translation and RNA Processing of Synaptic Proteins in Autism Spectrum Disorder

Department of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
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Author to whom correspondence should be addressed.
Academic Editor: Kunio Yui
Int. J. Mol. Sci. 2021, 22(6), 2811; https://doi.org/10.3390/ijms22062811
Received: 17 February 2021 / Revised: 5 March 2021 / Accepted: 6 March 2021 / Published: 10 March 2021
(This article belongs to the Special Issue Pathogenesis and Treatment of Autism Spectrum Disorders)
Autism spectrum disorder (ASD) is a heritable neurodevelopmental condition associated with impairments in social interaction, communication and repetitive behaviors. While the underlying disease mechanisms remain to be fully elucidated, dysfunction of neuronal plasticity and local translation control have emerged as key points of interest. Translation of mRNAs for critical synaptic proteins are negatively regulated by Fragile X mental retardation protein (FMRP), which is lost in the most common single-gene disorder associated with ASD. Numerous studies have shown that mRNA transport, RNA metabolism, and translation of synaptic proteins are important for neuronal health, synaptic plasticity, and learning and memory. Accordingly, dysfunction of these mechanisms may contribute to the abnormal brain function observed in individuals with autism spectrum disorder (ASD). In this review, we summarize recent studies about local translation and mRNA processing of synaptic proteins and discuss how perturbations of these processes may be related to the pathophysiology of ASD. View Full-Text
Keywords: local translation; RNA processing; RNA binding protein; synaptic protein; neuronal plasticity; autism local translation; RNA processing; RNA binding protein; synaptic protein; neuronal plasticity; autism
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MDPI and ACS Style

Joo, Y.; Benavides, D.R. Local Protein Translation and RNA Processing of Synaptic Proteins in Autism Spectrum Disorder. Int. J. Mol. Sci. 2021, 22, 2811. https://doi.org/10.3390/ijms22062811

AMA Style

Joo Y, Benavides DR. Local Protein Translation and RNA Processing of Synaptic Proteins in Autism Spectrum Disorder. International Journal of Molecular Sciences. 2021; 22(6):2811. https://doi.org/10.3390/ijms22062811

Chicago/Turabian Style

Joo, Yuyoung, and David R. Benavides. 2021. "Local Protein Translation and RNA Processing of Synaptic Proteins in Autism Spectrum Disorder" International Journal of Molecular Sciences 22, no. 6: 2811. https://doi.org/10.3390/ijms22062811

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