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Article

Shorter P1m Response in Children with Autism Spectrum Disorder without Intellectual Disabilities

1
Institute of Human and Social Sciences, Kanazawa University, Kanazawa 920-1192, Japan
2
Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan
3
Higher Brain Function & Autism Research, United Graduate School of Child Development, Kanazawa University, Kanazawa 920-8640, Japan
4
Human Communication Science & Intervention, United Graduate School of Child Development, Kanazawa University, Kanazawa 920-8640, Japan
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Faculty of Psychology, Yasuda Women’s University, Hiroshima 731-0153, Japan
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Department of Preventive Intervention for Psychiatric Disorders, National Center of Neurology and Psychiatry, Tokyo 187-8553, Japan
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Department of Biofunctional Imaging, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan
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Socio-Neuro Science, United Graduate School of Child Development, Kanazawa University, Kanazawa 920-8640, Japan
9
Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8641, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Kunio Yui
Int. J. Mol. Sci. 2021, 22(5), 2611; https://doi.org/10.3390/ijms22052611
Received: 28 January 2021 / Revised: 1 March 2021 / Accepted: 1 March 2021 / Published: 5 March 2021
(This article belongs to the Special Issue Pathogenesis and Treatment of Autism Spectrum Disorders)
(1) Background: Atypical auditory perception has been reported in individuals with autism spectrum disorder (ASD). Altered auditory evoked brain responses are also associated with childhood ASD. They are likely to be associated with atypical brain maturation. (2) Methods: This study examined children aged 5–8 years old: 29 with ASD but no intellectual disability and 46 age-matched typically developed (TD) control participants. Using magnetoencephalography (MEG) data obtained while participants listened passively to sinusoidal pure tones, bilateral auditory cortical response (P1m) was examined. (3) Results: Significantly shorter P1m latency in the left hemisphere was found for children with ASD without intellectual disabilities than for children with TD. Significant correlation between P1m latency and language conceptual ability was found in children with ASD, but not in children with TD. (4) Conclusions: These findings demonstrated atypical brain maturation in the auditory processing area in children with ASD without intellectual disability. Findings also suggest that ASD has a common neural basis for pure-tone sound processing and language development. Development of brain networks involved in language concepts in early childhood ASD might differ from that in children with TD. View Full-Text
Keywords: autism spectrum disorder; auditory cortex; P1m response; magnetoencephalography autism spectrum disorder; auditory cortex; P1m response; magnetoencephalography
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MDPI and ACS Style

Yoshimura, Y.; Ikeda, T.; Hasegawa, C.; An, K.-M.; Tanaka, S.; Yaoi, K.; Iwasaki, S.; Saito, D.N.; Kumazaki, H.; Hiraishi, H.; Kikuchi, M. Shorter P1m Response in Children with Autism Spectrum Disorder without Intellectual Disabilities. Int. J. Mol. Sci. 2021, 22, 2611. https://doi.org/10.3390/ijms22052611

AMA Style

Yoshimura Y, Ikeda T, Hasegawa C, An K-M, Tanaka S, Yaoi K, Iwasaki S, Saito DN, Kumazaki H, Hiraishi H, Kikuchi M. Shorter P1m Response in Children with Autism Spectrum Disorder without Intellectual Disabilities. International Journal of Molecular Sciences. 2021; 22(5):2611. https://doi.org/10.3390/ijms22052611

Chicago/Turabian Style

Yoshimura, Yuko, Takashi Ikeda, Chiaki Hasegawa, Kyung-Min An, Sanae Tanaka, Ken Yaoi, Sumie Iwasaki, Daisuke N. Saito, Hirokazu Kumazaki, Hirotoshi Hiraishi, and Mitsuru Kikuchi. 2021. "Shorter P1m Response in Children with Autism Spectrum Disorder without Intellectual Disabilities" International Journal of Molecular Sciences 22, no. 5: 2611. https://doi.org/10.3390/ijms22052611

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