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Review

Tight Junctions as a Key for Pathogens Invasion in Intestinal Epithelial Cells

1
UMR PAM l’Université de Bourgogne Franche-Comté (UBFC), AgroSup Dijon, Equipe Vin, Aliment, Microbiologie, Stress, F21000 Dijon, France
2
Laboratoire de Parasitologie-Mycologie, Plateforme de Biologie Hospitalo-Universitaire Gérard Mack, F21000 Dijon, France
*
Author to whom correspondence should be addressed.
Academic Editors: Véronique Carrière and Sophie Thenet
Int. J. Mol. Sci. 2021, 22(5), 2506; https://doi.org/10.3390/ijms22052506
Received: 11 February 2021 / Revised: 21 February 2021 / Accepted: 23 February 2021 / Published: 2 March 2021
(This article belongs to the Special Issue Regulation and Physiopathology of Gut Barrier)
Tight junctions play a major role in maintaining the integrity and impermeability of the intestinal barrier. As such, they act as an ideal target for pathogens to promote their translocation through the intestinal mucosa and invade their host. Different strategies are used by pathogens, aimed at directly destabilizing the junctional network or modulating the different signaling pathways involved in the modulation of these junctions. After a brief presentation of the organization and modulation of tight junctions, we provide the state of the art of the molecular mechanisms leading to permeability breakdown of the gut barrier as a consequence of tight junctions’ attack by pathogens, including bacteria, viruses, fungi, and parasites. View Full-Text
Keywords: enterocytes; gut barrier; tight junction; intestinal epithelial cells; pathogens; microorganisms; signaling pathways; permeability enterocytes; gut barrier; tight junction; intestinal epithelial cells; pathogens; microorganisms; signaling pathways; permeability
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MDPI and ACS Style

Paradis, T.; Bègue, H.; Basmaciyan, L.; Dalle, F.; Bon, F. Tight Junctions as a Key for Pathogens Invasion in Intestinal Epithelial Cells. Int. J. Mol. Sci. 2021, 22, 2506. https://doi.org/10.3390/ijms22052506

AMA Style

Paradis T, Bègue H, Basmaciyan L, Dalle F, Bon F. Tight Junctions as a Key for Pathogens Invasion in Intestinal Epithelial Cells. International Journal of Molecular Sciences. 2021; 22(5):2506. https://doi.org/10.3390/ijms22052506

Chicago/Turabian Style

Paradis, Tracy, Hervé Bègue, Louise Basmaciyan, Frédéric Dalle, and Fabienne Bon. 2021. "Tight Junctions as a Key for Pathogens Invasion in Intestinal Epithelial Cells" International Journal of Molecular Sciences 22, no. 5: 2506. https://doi.org/10.3390/ijms22052506

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