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The Nerves to Conduct a Multiple Sclerosis Crime Investigation

by 1,2,3,4, 1,2,3, 1,2,3 and 1,2,3,*
1
McCaig Institute for Bone and Joint Health, Calgary, AB T2N 4N1, Canada
2
Department of Physiology and Pharmacology, University of Calgary, Calgary, AB T2N 4N1, Canada
3
Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB T2N 4N1, Canada
4
Faculty of Health Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Soraya L. Valles
Int. J. Mol. Sci. 2021, 22(5), 2498; https://doi.org/10.3390/ijms22052498
Received: 1 February 2021 / Revised: 25 February 2021 / Accepted: 25 February 2021 / Published: 2 March 2021
(This article belongs to the Special Issue Changes Produced by Viruses and Bacteria on the Nervous System)
Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative autoimmune disease characterized by the aberrant infiltration of immune cells into the central nervous system (CNS) and by the loss of myelin. Sclerotic lesions and various inhibitory factors hamper the remyelination processes within the CNS. MS patients typically experience gradual cognitive and physical disabilities as the disease progresses. The etiology of MS is still unclear and emerging evidence suggests that microbiome composition could play a much more significant role in disease pathogenesis than was initially thought. Initially believed to be isolated to the gut microenvironment, we now know that the microbiome plays a much broader role in various tissues and is essential in the development of the immune system. Here, we present some of the unexpected roles that the microbiome plays in MS and discuss approaches for the development of next-generation treatment strategies. View Full-Text
Keywords: multiple sclerosis (MS); microbiome; bacteria; virus; central nervous system (CNS); immunity multiple sclerosis (MS); microbiome; bacteria; virus; central nervous system (CNS); immunity
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MDPI and ACS Style

Chopra, S.; Myers, Z.; Sekhon, H.; Dufour, A. The Nerves to Conduct a Multiple Sclerosis Crime Investigation. Int. J. Mol. Sci. 2021, 22, 2498. https://doi.org/10.3390/ijms22052498

AMA Style

Chopra S, Myers Z, Sekhon H, Dufour A. The Nerves to Conduct a Multiple Sclerosis Crime Investigation. International Journal of Molecular Sciences. 2021; 22(5):2498. https://doi.org/10.3390/ijms22052498

Chicago/Turabian Style

Chopra, Sameeksha, Zoë Myers, Henna Sekhon, and Antoine Dufour. 2021. "The Nerves to Conduct a Multiple Sclerosis Crime Investigation" International Journal of Molecular Sciences 22, no. 5: 2498. https://doi.org/10.3390/ijms22052498

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