Next Article in Journal
The Potential of Hydrogen Sulfide Donors in Treating Cardiovascular Diseases
Next Article in Special Issue
Cell-to-Cell Communication by Host-Released Extracellular Vesicles in the Gut: Implications in Health and Disease
Previous Article in Journal
New Insights into the Transcriptional Regulation of Genes Involved in the Nitrogen Use Efficiency under Potassium Chlorate in Rice (Oryza sativa L.)
Previous Article in Special Issue
Circulating Extracellular Vesicles: The Missing Link between Physical Exercise and Depression Management?
Open AccessReview

Integrin Regulation in Immunological and Cancerous Cells and Exosomes

1
Department of Physiology, University of Medicine, Magway, 7th Mile, Natmauk Road, Magway City 04012, Magway Region, Myanmar
2
Department of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu-City 514-8507, Mie, Japan
*
Authors to whom correspondence should be addressed.
Academic Editor: Henrique Girao
Int. J. Mol. Sci. 2021, 22(4), 2193; https://doi.org/10.3390/ijms22042193
Received: 17 January 2021 / Revised: 10 February 2021 / Accepted: 17 February 2021 / Published: 23 February 2021
Integrins represent the biologically and medically significant family of cell adhesion molecules that govern a wide range of normal physiology. The activities of integrins in cells are dynamically controlled via activation-dependent conformational changes regulated by the balance of intracellular activators, such as talin and kindlin, and inactivators, such as Shank-associated RH domain interactor (SHARPIN) and integrin cytoplasmic domain-associated protein 1 (ICAP-1). The activities of integrins are alternatively controlled by homotypic lateral association with themselves to induce integrin clustering and/or by heterotypic lateral engagement with tetraspanin and syndecan in the same cells to modulate integrin adhesiveness. It has recently emerged that integrins are expressed not only in cells but also in exosomes, important entities of extracellular vesicles secreted from cells. Exosomal integrins have received considerable attention in recent years, and they are clearly involved in determining the tissue distribution of exosomes, forming premetastatic niches, supporting internalization of exosomes by target cells and mediating exosome-mediated transfer of the membrane proteins and associated kinases to target cells. A growing body of evidence shows that tumor and immune cell exosomes have the ability to alter endothelial characteristics (proliferation, migration) and gene expression, some of these effects being facilitated by vesicle-bound integrins. As endothelial metabolism is now thought to play a key role in tumor angiogenesis, we also discuss how tumor cells and their exosomes pleiotropically modulate endothelial functions in the tumor microenvironment. View Full-Text
Keywords: integrin; exosome; talin; kindlin; endothelial metabolism; angiogenesis integrin; exosome; talin; kindlin; endothelial metabolism; angiogenesis
Show Figures

Figure 1

MDPI and ACS Style

Soe, Z.Y.; Park, E.J.; Shimaoka, M. Integrin Regulation in Immunological and Cancerous Cells and Exosomes. Int. J. Mol. Sci. 2021, 22, 2193. https://doi.org/10.3390/ijms22042193

AMA Style

Soe ZY, Park EJ, Shimaoka M. Integrin Regulation in Immunological and Cancerous Cells and Exosomes. International Journal of Molecular Sciences. 2021; 22(4):2193. https://doi.org/10.3390/ijms22042193

Chicago/Turabian Style

Soe, Zay Y.; Park, Eun J.; Shimaoka, Motomu. 2021. "Integrin Regulation in Immunological and Cancerous Cells and Exosomes" Int. J. Mol. Sci. 22, no. 4: 2193. https://doi.org/10.3390/ijms22042193

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop