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Review

Immune Checkpoint Inhibitor-Induced Diabetes Mellitus: Potential Role of T Cells in the Underlying Mechanism

1
Department of Internal Medicine, Endocrinology Division, Faculty of Medicine and Medical Center, American University of Beirut, Beirut 11072020, Lebanon
2
Department of Anatomy, Cell Biology, and Physiological Sciences, Faculty of Medicine and Medical Center, American University of Beirut, Beirut 11072020, Lebanon
3
American University of Beirut (AUB) Diabetes, Faculty of Medicine and Medical Center, American University of Beirut, Beirut 11072020, Lebanon
*
Author to whom correspondence should be addressed.
Academic Editor: Roberto Bei
Int. J. Mol. Sci. 2021, 22(4), 2093; https://doi.org/10.3390/ijms22042093
Received: 9 January 2021 / Revised: 30 January 2021 / Accepted: 2 February 2021 / Published: 20 February 2021
(This article belongs to the Section Biochemistry)
Immunotherapy is now a recognized treatment option for several types of cancer. However, some cancer patients treated with immune checkpoint inhibitors (ICIs) are subject to immune-related adverse events, including induced diabetes mellitus. The exact role and molecular/genetic action of ICIs in diabetes are still not well understood. Elucidating the underlying mechanisms in a proper fashion would allow better refining of biomarkers that would help diagnose patients at risk of altered immune system homeostasis, but would also hold the potential of new therapeutic options for diabetes. In the present narrative review, we propose to discuss the case of autoimmune diabetes following treatment with ICIs and the role of ICIs in the pathophysiology of diabetes. We also present some scarce available data on interesting potential immune therapies for diabetes. View Full-Text
Keywords: immune checkpoint inhibitors; immune-related adverse events; autoimmune diabetes; type I diabetes mellitus; immune checkpoint inhibitor-induced diabetes mellitus; PD-1; PD-L1; CTLA-4 immune checkpoint inhibitors; immune-related adverse events; autoimmune diabetes; type I diabetes mellitus; immune checkpoint inhibitor-induced diabetes mellitus; PD-1; PD-L1; CTLA-4
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MDPI and ACS Style

Mourad, D.; Azar, N.S.; Eid, A.A.; Azar, S.T. Immune Checkpoint Inhibitor-Induced Diabetes Mellitus: Potential Role of T Cells in the Underlying Mechanism. Int. J. Mol. Sci. 2021, 22, 2093. https://doi.org/10.3390/ijms22042093

AMA Style

Mourad D, Azar NS, Eid AA, Azar ST. Immune Checkpoint Inhibitor-Induced Diabetes Mellitus: Potential Role of T Cells in the Underlying Mechanism. International Journal of Molecular Sciences. 2021; 22(4):2093. https://doi.org/10.3390/ijms22042093

Chicago/Turabian Style

Mourad, Diane, Nadim S. Azar, Assaad A. Eid, and Sami T. Azar. 2021. "Immune Checkpoint Inhibitor-Induced Diabetes Mellitus: Potential Role of T Cells in the Underlying Mechanism" International Journal of Molecular Sciences 22, no. 4: 2093. https://doi.org/10.3390/ijms22042093

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