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Dermal Drivers of Injury-Induced Inflammation: Contribution of Adipocytes and Fibroblasts

Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Athena Soulika
Int. J. Mol. Sci. 2021, 22(4), 1933; https://doi.org/10.3390/ijms22041933
Received: 25 January 2021 / Revised: 11 February 2021 / Accepted: 15 February 2021 / Published: 16 February 2021
(This article belongs to the Special Issue Immune Responses in Wound Healing and Tissue Reconstruction)
Irregular inflammatory responses are a major contributor to tissue dysfunction and inefficient repair. Skin has proven to be a powerful model to study mechanisms that regulate inflammation. In particular, skin wound healing is dependent on a rapid, robust immune response and subsequent dampening of inflammatory signaling. While injury-induced inflammation has historically been attributed to keratinocytes and immune cells, a vast body of evidence supports the ability of non-immune cells to coordinate inflammation in numerous tissues and diseases. In this review, we concentrate on the active participation of tissue-resident adipocytes and fibroblasts in pro-inflammatory signaling after injury, and how altered cellular communication from these cells can contribute to irregular inflammation associated with aberrant wound healing. Furthering our understanding of how tissue-resident mesenchymal cells contribute to inflammation will likely reveal new targets that can be manipulated to regulate inflammation and repair. View Full-Text
Keywords: inflammation; adipocyte; fibroblast; wound healing; diabetes; aging inflammation; adipocyte; fibroblast; wound healing; diabetes; aging
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MDPI and ACS Style

Cooper, P.O.; Haas, M.R.; Noonepalle, S.k.R.; Shook, B.A. Dermal Drivers of Injury-Induced Inflammation: Contribution of Adipocytes and Fibroblasts. Int. J. Mol. Sci. 2021, 22, 1933. https://doi.org/10.3390/ijms22041933

AMA Style

Cooper PO, Haas MR, Noonepalle SkR, Shook BA. Dermal Drivers of Injury-Induced Inflammation: Contribution of Adipocytes and Fibroblasts. International Journal of Molecular Sciences. 2021; 22(4):1933. https://doi.org/10.3390/ijms22041933

Chicago/Turabian Style

Cooper, Paula O.; Haas, MaryEllen R.; Noonepalle, Satish k.R.; Shook, Brett A. 2021. "Dermal Drivers of Injury-Induced Inflammation: Contribution of Adipocytes and Fibroblasts" Int. J. Mol. Sci. 22, no. 4: 1933. https://doi.org/10.3390/ijms22041933

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