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Open AccessCase Report

40-Hz Auditory Steady-State Response (ASSR) as a Biomarker of Genetic Defects in the SHANK3 Gene: A Case Report of 15-Year-Old Girl with a Rare Partial SHANK3 Duplication

1
Laboratory of Human Higher Nervous Activity, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Science, 117485 Moscow, Russia
2
Veltischev Research and Clinical Institute for Pediatrics of the Pirogov, Russian National Research Medical University, Ministry of Health of Russian Federation, 125412 Moscow, Russia
3
Mental Health Research Center, 117152 Moscow, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Merlin G. Butler
Int. J. Mol. Sci. 2021, 22(4), 1898; https://doi.org/10.3390/ijms22041898
Received: 12 January 2021 / Revised: 26 January 2021 / Accepted: 9 February 2021 / Published: 14 February 2021
SHANK3 encodes a scaffold protein involved in postsynaptic receptor density in glutamatergic synapses, including those in the parvalbumin (PV)+ inhibitory neurons—the key players in the generation of sensory gamma oscillations, such as 40-Hz auditory steady-state response (ASSR). However, 40-Hz ASSR was not studied in relation to SHANK3 functioning. Here, we present a 15-year-old girl (SH01) with previously unreported duplication of the first seven exons of the SHANK3 gene (22q13.33). SH01’s electroencephalogram (EEG) during 40-Hz click trains of 500 ms duration binaurally presented with inter-trial intervals of 500–800 ms were compared with those from typically developing children (n = 32). SH01 was diagnosed with mild mental retardation and learning disabilities (F70.88), dysgraphia, dyslexia, and smaller vocabulary than typically developing (TD) peers. Her clinical phenotype resembled the phenotype of previously described patients with 22q13.33 microduplications (≈30 reported so far). SH01 had mild autistic symptoms but below the threshold for ASD diagnosis and microcephaly. No seizures or MRI abnormalities were reported. While SH01 had relatively preserved auditory event-related potential (ERP) with slightly attenuated P1, her 40-Hz ASSR was totally absent significantly deviating from TD’s ASSR. The absence of 40-Hz ASSR in patients with microduplication, which affected the SHANK3 gene, indicates deficient temporal resolution of the auditory system, which might underlie language problems and represent a neurophysiological biomarker of SHANK3 abnormalities. View Full-Text
Keywords: 22q13.3 duplication; auditory steady-state response; ASSR; SHANK3; biomarker; auditory event-related potential; ERP; autism spectrum disorders; intellectual disabilities 22q13.3 duplication; auditory steady-state response; ASSR; SHANK3; biomarker; auditory event-related potential; ERP; autism spectrum disorders; intellectual disabilities
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MDPI and ACS Style

Neklyudova, A.K.; Portnova, G.V.; Rebreikina, A.B.; Voinova, V.Y.; Vorsanova, S.G.; Iourov, I.Y.; Sysoeva, O.V. 40-Hz Auditory Steady-State Response (ASSR) as a Biomarker of Genetic Defects in the SHANK3 Gene: A Case Report of 15-Year-Old Girl with a Rare Partial SHANK3 Duplication. Int. J. Mol. Sci. 2021, 22, 1898. https://doi.org/10.3390/ijms22041898

AMA Style

Neklyudova AK, Portnova GV, Rebreikina AB, Voinova VY, Vorsanova SG, Iourov IY, Sysoeva OV. 40-Hz Auditory Steady-State Response (ASSR) as a Biomarker of Genetic Defects in the SHANK3 Gene: A Case Report of 15-Year-Old Girl with a Rare Partial SHANK3 Duplication. International Journal of Molecular Sciences. 2021; 22(4):1898. https://doi.org/10.3390/ijms22041898

Chicago/Turabian Style

Neklyudova, Anastasia K.; Portnova, Galina V.; Rebreikina, Anna B.; Voinova, Victoria Y.; Vorsanova, Svetlana G.; Iourov, Ivan Y.; Sysoeva, Olga V. 2021. "40-Hz Auditory Steady-State Response (ASSR) as a Biomarker of Genetic Defects in the SHANK3 Gene: A Case Report of 15-Year-Old Girl with a Rare Partial SHANK3 Duplication" Int. J. Mol. Sci. 22, no. 4: 1898. https://doi.org/10.3390/ijms22041898

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