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Review

“Empowering” Cardiac Cells via Stem Cell Derived Mitochondrial Transplantation- Does Age Matter?

by 1,2 and 1,2,*
1
Laboratory Animal Science Unit, Leibniz-Institut für Primatenforschung, Deutsches Primatenzentrum GmbH, Kellnerweg 4, 37077 Göttingen, Germany
2
DZHK (German Center for Cardiovascular Research), partner site Göttingen, 37077 Göttingen, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(4), 1824; https://doi.org/10.3390/ijms22041824
Received: 30 December 2020 / Revised: 8 February 2021 / Accepted: 9 February 2021 / Published: 12 February 2021
(This article belongs to the Special Issue Stem Cells Aging)
With cardiovascular diseases affecting millions of patients, new treatment strategies are urgently needed. The use of stem cell based approaches has been investigated during the last decades and promising effects have been achieved. However, the beneficial effect of stem cells has been found to being partly due to paracrine functions by alterations of their microenvironment and so an interesting field of research, the “stem- less” approaches has emerged over the last years using or altering the microenvironment, for example, via deletion of senescent cells, application of micro RNAs or by modifying the cellular energy metabolism via targeting mitochondria. Using autologous muscle-derived mitochondria for transplantations into the affected tissues has resulted in promising reports of improvements of cardiac functions in vitro and in vivo. However, since the targeted treatment group represents mainly elderly or otherwise sick patients, it is unclear whether and to what extent autologous mitochondria would exert their beneficial effects in these cases. Stem cells might represent better sources for mitochondria and could enhance the effect of mitochondrial transplantations. Therefore in this review we aim to provide an overview on aging effects of stem cells and mitochondria which might be important for mitochondrial transplantation and to give an overview on the current state in this field together with considerations worthwhile for further investigations. View Full-Text
Keywords: stem cell; aging; senescence; mitochondria; transplantation; cardiovascular; heart stem cell; aging; senescence; mitochondria; transplantation; cardiovascular; heart
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MDPI and ACS Style

Mietsch, M.; Hinkel, R. “Empowering” Cardiac Cells via Stem Cell Derived Mitochondrial Transplantation- Does Age Matter? Int. J. Mol. Sci. 2021, 22, 1824. https://doi.org/10.3390/ijms22041824

AMA Style

Mietsch M, Hinkel R. “Empowering” Cardiac Cells via Stem Cell Derived Mitochondrial Transplantation- Does Age Matter? International Journal of Molecular Sciences. 2021; 22(4):1824. https://doi.org/10.3390/ijms22041824

Chicago/Turabian Style

Mietsch, Matthias, and Rabea Hinkel. 2021. "“Empowering” Cardiac Cells via Stem Cell Derived Mitochondrial Transplantation- Does Age Matter?" International Journal of Molecular Sciences 22, no. 4: 1824. https://doi.org/10.3390/ijms22041824

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