ERK-Directed Phosphorylation of mGlu5 Gates Methamphetamine Reward and Reinforcement in Mouse
Abstract
:1. Introduction
2. Results
2.1. pERK Expression within mPFC Predicts the Positive Affective Valence of MA
2.2. U0126 Reduces MA-Induced Place-Preference
2.3. Transgenic Disruption of ERK-Dependent Phosphorylation of (T1123/S1126)mGlu5 Augments MA-Conditioned Reward
2.4. Transgenic Disruption of ERK-Dependent Phosphorylation of (T1123/S1126)mGlu5 Does Not Affect MA-Induced Locomotion or Locomotor Sensitization
2.5. Transgenic Disruption of ERK-Dependent Phosphorylation of T1123/S1126-mGlu5 Robustly Attenuates Oral MA Reinforcement and Intake
2.6. Acquisition of Self-Administration
2.7. MA Demand under Increasing Response Requirement
2.8. Dose-Response Function for Oral MA Reinforcement
2.9. Transgenic Disruption of ERK-Dependent Phosphorylation of (T1123/S1126)mGlu5 Blunts Oral MA Intake under DID Procedures
3. Discussion
3.1. Individual Differences in MA-Preference Are Positively Correlated with ERK Hyper-Activity within PFC
3.2. Local Inhibition of mPFC ERK Phosphorylation Eliminates an Established MA-CPP Phenotype
3.3. Grm5AA/AA Mice Exhibit More Robust MA-CPP
3.4. Grm5AA/AA Mice Exhibit Reduced Oral MA Self-Administration
4. Materials and Methods
4.1. Subjects
4.2. Place-Conditioning and Locomotor Activity
4.3. Operant-Conditioning for Oral Methamphetamine Reinforcement
4.4. Methamphetamine Intake under Drinking-in-the-Dark Procedures
4.5. Stereotaxic Surgery, U0126 Microinjection, and Histology
4.6. Immunoblotting
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Fultz, E.K.; Quadir, S.G.; Martin, D.; Flaherty, D.M.; Worley, P.F.; Kippin, T.E.; Szumlinski, K.K. ERK-Directed Phosphorylation of mGlu5 Gates Methamphetamine Reward and Reinforcement in Mouse. Int. J. Mol. Sci. 2021, 22, 1473. https://doi.org/10.3390/ijms22031473
Fultz EK, Quadir SG, Martin D, Flaherty DM, Worley PF, Kippin TE, Szumlinski KK. ERK-Directed Phosphorylation of mGlu5 Gates Methamphetamine Reward and Reinforcement in Mouse. International Journal of Molecular Sciences. 2021; 22(3):1473. https://doi.org/10.3390/ijms22031473
Chicago/Turabian StyleFultz, Elissa K., Sema G. Quadir, Douglas Martin, Daniel M. Flaherty, Paul F. Worley, Tod E. Kippin, and Karen K. Szumlinski. 2021. "ERK-Directed Phosphorylation of mGlu5 Gates Methamphetamine Reward and Reinforcement in Mouse" International Journal of Molecular Sciences 22, no. 3: 1473. https://doi.org/10.3390/ijms22031473