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Open AccessReview

Tumor Metabolic Reprogramming by Adipokines as a Critical Driver of Obesity-Associated Cancer Progression

by 1 and 1,2,*
1
College of Pharmacy, Yeungnam University, Gyeongsan 38541, Korea
2
Research Institute of Cell Culture, Yeungnam University, Gyeongsan 38541, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Paola Maroni
Int. J. Mol. Sci. 2021, 22(3), 1444; https://doi.org/10.3390/ijms22031444
Received: 23 December 2020 / Revised: 28 January 2021 / Accepted: 28 January 2021 / Published: 1 February 2021
Adiposity is associated with an increased risk of various types of carcinoma. One of the plausible mechanisms underlying the tumor-promoting role of obesity is an aberrant secretion of adipokines, a group of hormones secreted from adipose tissue, which have exhibited both oncogenic and tumor-suppressing properties in an adipokine type- and context-dependent manner. Increasing evidence has indicated that these adipose tissue-derived hormones differentially modulate cancer cell-specific metabolism. Some adipokines, such as leptin, resistin, and visfatin, which are overproduced in obesity and widely implicated in different stages of cancer, promote cellular glucose and lipid metabolism. Conversely, adiponectin, an adipokine possessing potent anti-tumor activities, is linked to a more favorable metabolic phenotype. Adipokines may also play a pivotal role under the reciprocal regulation of metabolic rewiring of cancer cells in tumor microenvironment. Given the fact that metabolic reprogramming is one of the major hallmarks of cancer, understanding the modulatory effects of adipokines on alterations in cancer cell metabolism would provide insight into the crosstalk between obesity, adipokines, and tumorigenesis. In this review, we summarize recent insights into putative roles of adipokines as mediators of cellular metabolic rewiring in obesity-associated tumors, which plays a crucial role in determining the fate of tumor cells. View Full-Text
Keywords: adipokine; cancer metabolism; metabolic reprogramming; obesity adipokine; cancer metabolism; metabolic reprogramming; obesity
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MDPI and ACS Style

Pham, D.-V.; Park, P.-H. Tumor Metabolic Reprogramming by Adipokines as a Critical Driver of Obesity-Associated Cancer Progression. Int. J. Mol. Sci. 2021, 22, 1444. https://doi.org/10.3390/ijms22031444

AMA Style

Pham D-V, Park P-H. Tumor Metabolic Reprogramming by Adipokines as a Critical Driver of Obesity-Associated Cancer Progression. International Journal of Molecular Sciences. 2021; 22(3):1444. https://doi.org/10.3390/ijms22031444

Chicago/Turabian Style

Pham, Duc-Vinh; Park, Pil-Hoon. 2021. "Tumor Metabolic Reprogramming by Adipokines as a Critical Driver of Obesity-Associated Cancer Progression" Int. J. Mol. Sci. 22, no. 3: 1444. https://doi.org/10.3390/ijms22031444

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