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DNA Methylation in T-Cell Acute Lymphoblastic Leukemia: In Search for Clinical and Biological Meaning

Institute of Human Genetics Polish Academy of Sciences, 60-479 Poznań, Poland
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Academic Editors: Maria M. Sasiadek and Pawel Karpinski
Int. J. Mol. Sci. 2021, 22(3), 1388; https://doi.org/10.3390/ijms22031388
Received: 24 December 2020 / Revised: 22 January 2021 / Accepted: 23 January 2021 / Published: 30 January 2021
(This article belongs to the Special Issue Epigenetic Mechanisms and Human Pathology)
Distinct DNA methylation signatures, related to different prognosis, have been observed across many cancers, including T-cell acute lymphoblastic leukemia (T-ALL), an aggressive hematological neoplasm. By global methylation analysis, two major phenotypes might be observed in T-ALL: hypermethylation related to better outcome and hypomethylation, which is a candidate marker of poor prognosis. Moreover, DNA methylation holds more than a clinical meaning. It reflects the replicative history of leukemic cells and most likely different mechanisms underlying leukemia development in these T-ALL subtypes. The elucidation of the mechanisms and aberrations specific to (epi-)genomic subtypes might pave the way towards predictive diagnostics and precision medicine in T-ALL. We present the current state of knowledge on the role of DNA methylation in T-ALL. We describe the involvement of DNA methylation in normal hematopoiesis and T-cell development, focusing on epigenetic aberrations contributing to this leukemia. We further review the research investigating distinct methylation phenotypes in T-ALL, related to different outcomes, pointing to the most recent research aimed to unravel the biological mechanisms behind differential methylation. We highlight how technological advancements facilitated broadening the perspective of the investigation into DNA methylation and how this has changed our understanding of the roles of this epigenetic modification in T-ALL. View Full-Text
Keywords: T-cell acute lymphoblastic leukemia; T-ALL; DNA methylation; epigenetic aberrations; epigenetic prognostic markers; methylation phenotypes in cancer T-cell acute lymphoblastic leukemia; T-ALL; DNA methylation; epigenetic aberrations; epigenetic prognostic markers; methylation phenotypes in cancer
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MDPI and ACS Style

Maćkowska, N.; Drobna-Śledzińska, M.; Witt, M.; Dawidowska, M. DNA Methylation in T-Cell Acute Lymphoblastic Leukemia: In Search for Clinical and Biological Meaning. Int. J. Mol. Sci. 2021, 22, 1388. https://doi.org/10.3390/ijms22031388

AMA Style

Maćkowska N, Drobna-Śledzińska M, Witt M, Dawidowska M. DNA Methylation in T-Cell Acute Lymphoblastic Leukemia: In Search for Clinical and Biological Meaning. International Journal of Molecular Sciences. 2021; 22(3):1388. https://doi.org/10.3390/ijms22031388

Chicago/Turabian Style

Maćkowska, Natalia, Monika Drobna-Śledzińska, Michał Witt, and Małgorzata Dawidowska. 2021. "DNA Methylation in T-Cell Acute Lymphoblastic Leukemia: In Search for Clinical and Biological Meaning" International Journal of Molecular Sciences 22, no. 3: 1388. https://doi.org/10.3390/ijms22031388

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