The Protective Role of Sestrin2 in Atherosclerotic and Cardiac Diseases
Abstract
:1. Introduction
2. Physiopathological Mechanisms of Sestrin2
2.1. Sestrin2 Signaling Pathways
2.2. Sestrin2 and Oxidative Stress
2.3. Sestrin2 and Inflammation
3. Sestrin2 and Cardiac Diseases
3.1. Aging and Myocardial Infarction
3.2. Cardiomyopathy
4. Sestrin2 and Atherosclerotic Diseases
4.1. Coronary Artery Disease
4.2. Carotid Atherosclerosis
4.3. Miscellaneous
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Study | Serum/Plasma | Study Subjects | Results |
---|---|---|---|
Rai et al. [41] | Serum | 51 frail elderly vs. 41 non-frail elderly | Lower in frail elderly than in non-frail elderly. |
Wang et al. [6] | Plasma | 220 patients with HF vs. 80 controls | Higher in patients with HF than in controls |
Xiao et al. [55] | Plasma | 120 patients with aortic dissection vs. 40 without dissection | Higher in patients with aortic dissection than in those without dissection |
Jiang et al. [56] | Plasma | 36 patients with OSA vs. 21 controls | Higher in patients with OSA than in controls |
Ye et al. [37] | Plasma | 114 patients with CAD (44 SA, 41 UA, 29 AMI) vs. 35 without CAD | Higher in patients with CAD than in those without CAD Higher in patients with UA and AMI than in those with SA |
Kishimoto et al. [39] | Plasma | 175 patients with CAD vs. 129 without CAD | Higher in patients with CAD than in those without CAD |
Sundararajan et al. [53] | Serum | 81 patients with DM vs. 46 controls (NGT) | Lower in patients with DM than in controls |
Chung et al. [38] | Serum | 194 patients with DM vs. 46 without DM | No difference between patients with and without DM |
Chung et al. [38] | Serum | 80 DM patients with carotid atherosclerosis vs. 114 DM without carotid atherosclerosis | No difference between DM patients with and without carotid atherosclerosis |
Kishimoto et al. [54] | Plasma | 63 subjects with carotid plaque vs. 89 without carotid plaque | Higher in subjects with carotid plaque than in those without carotid plaque |
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Kishimoto, Y.; Kondo, K.; Momiyama, Y. The Protective Role of Sestrin2 in Atherosclerotic and Cardiac Diseases. Int. J. Mol. Sci. 2021, 22, 1200. https://doi.org/10.3390/ijms22031200
Kishimoto Y, Kondo K, Momiyama Y. The Protective Role of Sestrin2 in Atherosclerotic and Cardiac Diseases. International Journal of Molecular Sciences. 2021; 22(3):1200. https://doi.org/10.3390/ijms22031200
Chicago/Turabian StyleKishimoto, Yoshimi, Kazuo Kondo, and Yukihiko Momiyama. 2021. "The Protective Role of Sestrin2 in Atherosclerotic and Cardiac Diseases" International Journal of Molecular Sciences 22, no. 3: 1200. https://doi.org/10.3390/ijms22031200