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Volume 22
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Review

Drug Reaction with Eosinophilia and Systemic Symptoms: A Complex Interplay between Drug, T Cells, and Herpesviridae

by
Luckshman Ganeshanandan
1,2,* and
Michaela Lucas
1,2,3
1
Department of Clinical Immunology, Sir Charles Gairdner Hospital, Perth, WA 6009, Australia
2
PathWest Laboratory Medicine WA, Queen Elizabeth II Medical Centre, Perth, WA 6009, Australia
3
Faculty of Health and Medical Sciences, UWA Medical School, University of Western Australia, Perth, WA 6009, Australia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(3), 1127; https://doi.org/10.3390/ijms22031127
Submission received: 14 December 2020 / Revised: 14 January 2021 / Accepted: 20 January 2021 / Published: 23 January 2021
(This article belongs to the Special Issue Recent Advances in T Cell Immunity)
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Abstract

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, also known as drug induced hypersensitivity (DiHS) syndrome is a severe delayed hypersensitivity reaction with potentially fatal consequences. Whilst recognised as T cell-mediated, our understanding of the immunopathogenesis of this syndrome remains incomplete. Here, we discuss models of DRESS, including the role of human leukocyte antigen (HLA) and how observations derived from new molecular techniques adopted in key studies have informed our mechanism-based understanding of the central role of Herpesviridae reactivation and heterologous immunity in these disorders.
Keywords: drug induced hypersensitivity syndrome; Herpesviridae; reaction; eosinophilia drug induced hypersensitivity syndrome; Herpesviridae; reaction; eosinophilia

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MDPI and ACS Style

Ganeshanandan, L.; Lucas, M. Drug Reaction with Eosinophilia and Systemic Symptoms: A Complex Interplay between Drug, T Cells, and Herpesviridae. Int. J. Mol. Sci. 2021, 22, 1127. https://doi.org/10.3390/ijms22031127

AMA Style

Ganeshanandan L, Lucas M. Drug Reaction with Eosinophilia and Systemic Symptoms: A Complex Interplay between Drug, T Cells, and Herpesviridae. International Journal of Molecular Sciences. 2021; 22(3):1127. https://doi.org/10.3390/ijms22031127

Chicago/Turabian Style

Ganeshanandan, Luckshman, and Michaela Lucas. 2021. "Drug Reaction with Eosinophilia and Systemic Symptoms: A Complex Interplay between Drug, T Cells, and Herpesviridae" International Journal of Molecular Sciences 22, no. 3: 1127. https://doi.org/10.3390/ijms22031127

APA Style

Ganeshanandan, L., & Lucas, M. (2021). Drug Reaction with Eosinophilia and Systemic Symptoms: A Complex Interplay between Drug, T Cells, and Herpesviridae. International Journal of Molecular Sciences, 22(3), 1127. https://doi.org/10.3390/ijms22031127

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