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Article

Alteration of Pituitary Tumor Transforming Gene 1 by MicroRNA-186 and 655 Regulates Invasion Ability of Human Oral Squamous Cell Carcinoma

1
Department of Oral Pathology, College of Dentistry, Gangneung-Wonju National University, Gangneung 25457, Korea
2
Department of Biomedical Science, CHA University, Seoul 13488, Korea
3
Department of Pathology, Seoul National University College of Medicine, Seoul 03080, Korea
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(3), 1021; https://doi.org/10.3390/ijms22031021
Received: 25 November 2020 / Revised: 11 January 2021 / Accepted: 18 January 2021 / Published: 20 January 2021
(This article belongs to the Special Issue New Regulators and Modulators of MicroRNA 2022)
Background: Pituitary tumor-transforming gene 1 (PTTG1) was recently shown to be involved in the progression as well as the metastasis of cancers. However, their expression and function in the invasion of oral squamous cell carcinoma (SCC) remain unclear. Methods: The expressions of PTTG1 and PTTG1-targeted miRNA in oral SCC cell lines and their invasion capability depended on PTTG1 expression were analyzed by quantitative RT-PCR, Western blots, the transwell insert system and Zymography. Results: Invasion abilities were decreased in oral SCC cells treated with siRNA-PTTG1. When PTTG1 were downregulated in oral SCC cells treated with microRNA-186 and -655 inhibited their invasion abilities via MMP-9 activity. Conclusions: These results indicate that alteration of expression of PTTG1 in oral SCC cells by newly identified microRNA-186 and -655 can regulate invasion activity. Therefore, these data offer new insights into further understanding PTTG1 function in oral SCC and should provide new strategies for diagnostic markers for oral SCC. View Full-Text
Keywords: pituitary tumor-transforming gene 1; oral squamous cell carcinoma; invasion; microRNA pituitary tumor-transforming gene 1; oral squamous cell carcinoma; invasion; microRNA
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MDPI and ACS Style

Lee, S.S.; Choi, J.H.; Lim, S.M.; Kim, G.J.; Lee, S.K.; Jeon, Y.K. Alteration of Pituitary Tumor Transforming Gene 1 by MicroRNA-186 and 655 Regulates Invasion Ability of Human Oral Squamous Cell Carcinoma. Int. J. Mol. Sci. 2021, 22, 1021. https://doi.org/10.3390/ijms22031021

AMA Style

Lee SS, Choi JH, Lim SM, Kim GJ, Lee SK, Jeon YK. Alteration of Pituitary Tumor Transforming Gene 1 by MicroRNA-186 and 655 Regulates Invasion Ability of Human Oral Squamous Cell Carcinoma. International Journal of Molecular Sciences. 2021; 22(3):1021. https://doi.org/10.3390/ijms22031021

Chicago/Turabian Style

Lee, Sang S., Jong H. Choi, Seung M. Lim, Gi J. Kim, Suk K. Lee, and Yoon K. Jeon. 2021. "Alteration of Pituitary Tumor Transforming Gene 1 by MicroRNA-186 and 655 Regulates Invasion Ability of Human Oral Squamous Cell Carcinoma" International Journal of Molecular Sciences 22, no. 3: 1021. https://doi.org/10.3390/ijms22031021

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