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Deepening the Knowledge of ROS1 Rearrangements in Non-Small Cell Lung Cancer: Diagnosis, Treatment, Resistance and Concomitant Alterations
Review

Ferroptosis in Non-Small Cell Lung Cancer: Progression and Therapeutic Potential on It

1
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
2
Department of Pharmacology, Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China
3
Department of Breast Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510275, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Carlo Genova
Int. J. Mol. Sci. 2021, 22(24), 13335; https://doi.org/10.3390/ijms222413335
Received: 21 October 2021 / Revised: 28 November 2021 / Accepted: 9 December 2021 / Published: 11 December 2021
As a main subtype of lung cancer, the current situation of non-small cell lung cancer (NSCLC) remains severe worldwide with a 19% survival rate at 5 years. As the conventional therapy approaches, such as chemotherapy, radiotherapy, targeted therapy, and immunotherapy, gradually develop into therapy resistance, searching for a novel therapeutic strategy for NSCLC is urgent. Ferroptosis, an iron-dependent programmed necrosis, has now been widely considered as a key factor affecting the tumorigenesis and progression in various cancers. Focusing on its effect in NSCLC, in different situations, ferroptosis can be triggered or restrained. When ferroptosis was induced in NSCLC, it was available to inhibit the tumor progression both in vitro and in vivo. The dominating mechanism was due to a regulation of the classic ferroptosis-repressed GSH-dependent GPX4 signaling pathway instead of other fractional regulating signal axes that regulated ferroptosis via impacting on the ROS, cellular iron levels, etc. In terms of the prevention of ferroptosis in NSCLC, an GSH-independent mechanism was also discovered, interestingly exhibiting the same upstream as the GPX4 signaling. In addition, this review summarizes the progression of ferroptosis in NSCLC and elaborates their association and specific mechanisms through bioinformatics analysis with multiple experimental evidence from different cascades. Finally, this review also points out the possibility of ferroptosis working as a novel strategy for therapy resistance in NSCLC, emphasizing its therapeutic potential. View Full-Text
Keywords: ferroptosis; NSCLC; progression; therapy resistance; natural drug ferroptosis; NSCLC; progression; therapy resistance; natural drug
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MDPI and ACS Style

Zou, J.; Wang, L.; Tang, H.; Liu, X.; Peng, F.; Peng, C. Ferroptosis in Non-Small Cell Lung Cancer: Progression and Therapeutic Potential on It. Int. J. Mol. Sci. 2021, 22, 13335. https://doi.org/10.3390/ijms222413335

AMA Style

Zou J, Wang L, Tang H, Liu X, Peng F, Peng C. Ferroptosis in Non-Small Cell Lung Cancer: Progression and Therapeutic Potential on It. International Journal of Molecular Sciences. 2021; 22(24):13335. https://doi.org/10.3390/ijms222413335

Chicago/Turabian Style

Zou, Jiayu, Li Wang, Hailin Tang, Xiuxiu Liu, Fu Peng, and Cheng Peng. 2021. "Ferroptosis in Non-Small Cell Lung Cancer: Progression and Therapeutic Potential on It" International Journal of Molecular Sciences 22, no. 24: 13335. https://doi.org/10.3390/ijms222413335

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