Next Article in Journal
Iota-Carrageenan Inhibits Replication of SARS-CoV-2 and the Respective Variants of Concern Alpha, Beta, Gamma and Delta
Next Article in Special Issue
Role of Autophagy in Lysophosphatidylcholine-Induced Apoptosis of Mouse Ovarian Granulosa Cells
Previous Article in Journal
Therapeutic Potential of TAAR1 Agonists in Schizophrenia: Evidence from Preclinical Models and Clinical Studies
Previous Article in Special Issue
Bisphenol A Modulates Autophagy and Exacerbates Chronic Kidney Damage in Mice
 
 
Article

Autism-Related Transcription Factors Underlying the Sex-Specific Effects of Prenatal Bisphenol A Exposure on Transcriptome-Interactome Profiles in the Offspring Prefrontal Cortex

1
The Ph.D. Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand
2
Systems Neuroscience of Autism and PSychiatric Disorders (SYNAPS) Research Unit, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand
3
Department of Anatomy, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
4
Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20052, USA
5
Department of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, Sendai 980-8577, Miyagi, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Ashis Basu
Int. J. Mol. Sci. 2021, 22(24), 13201; https://doi.org/10.3390/ijms222413201
Received: 22 November 2021 / Revised: 3 December 2021 / Accepted: 5 December 2021 / Published: 8 December 2021
Bisphenol A (BPA) is an environmental risk factor for autism spectrum disorder (ASD). BPA exposure dysregulates ASD-related genes in the hippocampus and neurological functions of offspring. However, whether prenatal BPA exposure has an impact on genes in the prefrontal cortex, another brain region highly implicated in ASD, and through what mechanisms have not been investigated. Here, we demonstrated that prenatal BPA exposure disrupts the transcriptome–interactome profiles of the prefrontal cortex of neonatal rats. Interestingly, the list of BPA-responsive genes was significantly enriched with known ASD candidate genes, as well as genes that were dysregulated in the postmortem brain tissues of ASD cases from multiple independent studies. Moreover, several differentially expressed genes in the offspring’s prefrontal cortex were the targets of ASD-related transcription factors, including AR, ESR1, and RORA. The hypergeometric distribution analysis revealed that BPA may regulate the expression of such genes through these transcription factors in a sex-dependent manner. The molecular docking analysis of BPA and ASD-related transcription factors revealed novel potential targets of BPA, including RORA, SOX5, TCF4, and YY1. Our findings indicated that prenatal BPA exposure disrupts ASD-related genes in the offspring’s prefrontal cortex and may increase the risk of ASD through sex-dependent molecular mechanisms, which should be investigated further. View Full-Text
Keywords: endocrine-disrupting chemical; bisphenol A; prenatal exposure; autism spectrum disorder; sex differences; transcription factor; transcriptome; interactome; prefrontal cortex; molecular docking endocrine-disrupting chemical; bisphenol A; prenatal exposure; autism spectrum disorder; sex differences; transcription factor; transcriptome; interactome; prefrontal cortex; molecular docking
Show Figures

Figure 1

MDPI and ACS Style

Kanlayaprasit, S.; Thongkorn, S.; Panjabud, P.; Jindatip, D.; Hu, V.W.; Kikkawa, T.; Osumi, N.; Sarachana, T. Autism-Related Transcription Factors Underlying the Sex-Specific Effects of Prenatal Bisphenol A Exposure on Transcriptome-Interactome Profiles in the Offspring Prefrontal Cortex. Int. J. Mol. Sci. 2021, 22, 13201. https://doi.org/10.3390/ijms222413201

AMA Style

Kanlayaprasit S, Thongkorn S, Panjabud P, Jindatip D, Hu VW, Kikkawa T, Osumi N, Sarachana T. Autism-Related Transcription Factors Underlying the Sex-Specific Effects of Prenatal Bisphenol A Exposure on Transcriptome-Interactome Profiles in the Offspring Prefrontal Cortex. International Journal of Molecular Sciences. 2021; 22(24):13201. https://doi.org/10.3390/ijms222413201

Chicago/Turabian Style

Kanlayaprasit, Songphon, Surangrat Thongkorn, Pawinee Panjabud, Depicha Jindatip, Valerie W. Hu, Takako Kikkawa, Noriko Osumi, and Tewarit Sarachana. 2021. "Autism-Related Transcription Factors Underlying the Sex-Specific Effects of Prenatal Bisphenol A Exposure on Transcriptome-Interactome Profiles in the Offspring Prefrontal Cortex" International Journal of Molecular Sciences 22, no. 24: 13201. https://doi.org/10.3390/ijms222413201

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop