Relationship between IgA Nephropathy and Porphyromonas gingivalis; Red Complex of Periodontopathic Bacterial Species

Department of Pediatric Dentistry, Division of Oral infection and Disease Control, Osaka University Graduate School of Dentistry, Suita 565-0871, Osaka, Japan

Division of Nephrology, Seirei Hamamatsu General Hospital, Shizuoka 430-8558, Hamamatsu, Japan

⁴

Department of Nursing, Faculty of Nursing, Seirei Christopher University, Shizuoka 433-8558, Hamamatsu, Japan

⁵

Department of Internal medicine, Japan Self-Defense Gifu Hospital, Gifu 502-0817, Kakamigahara, Japan

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Department of Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8525, Okayama, Japan

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Department of Otolaryngology, Meiwa Hospital, Nishinomiya 663-8186, Hyogo, Japan

⁸

Department of Otorhinolaryngology, Head and Neck Surgery, Hyogo College of Medicine, Nishinomiya 663-8501, Hyogo, Japan

Authors to whom correspondence should be addressed.

^†

Equally contributed to the study.

Academic Editor: Joan Torras-Ambròs

Int. J. Mol. Sci. 2021, 22(23), 13022; https://doi.org/10.3390/ijms222313022

Received: 8 October 2021 / Revised: 22 November 2021 / Accepted: 27 November 2021 / Published: 1 December 2021

(This article belongs to the Special Issue Infection and the Kidney)

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Abstract

IgA nephropathy (IgAN) has been considered to have a relationship with infection in the tonsil, because IgAN patients often manifest macro hematuria just after tonsillitis. In terms of oral-area infection, the red complex of periodontal bacteria (Porphyromonas gingivalis (P. gingivalis), Treponema denticol (T. denticola) and Tannerella forsythia (T. forsythia)) is important, but the relationship between these bacteria and IgAN remains unknown. In this study, the prevalence of the red complex of periodontal bacteria in tonsil was compared between IgAN and tonsillitis patients. The pathogenicity of IgAN induced by P. gingivalis was confirmed by the mice model treated with this bacterium. The prevalence of P. gingivalis and T. forsythia in IgAN patients was significantly higher than that in tonsillitis patients (p < 0.001 and p < 0.05, respectively). A total of 92% of tonsillitis patients were free from red complex bacteria, while only 48% of IgAN patients had any of these bacteria. Nasal administration of P. gingivalis in mice caused mesangial proliferation (p < 0.05 at days 28a nd 42; p < 0.01 at days 14 and 56) and IgA deposition (p < 0.001 at day 42 and 56 after administration). Scanning-electron-microscopic observation revealed that a high-density Electron-Dense Deposit was widely distributed in the mesangial region in the mice kidneys treated with P. gingivalis. These findings suggest that P. gingivalis is involved in the pathogenesis of IgAN. View Full-Text

Keywords: IgA nephropathy; periodontal bacteria; infection; mouse; tonsil; oral bacteria; Porphyromonas gingivalis

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MDPI and ACS Style

Nagasawa, Y.; Nomura, R.; Misaki, T.; Ito, S.; Naka, S.; Wato, K.; Okunaka, M.; Watabe, M.; Fushimi, K.; Tsuzuki, K.; Matsumoto-Nakano, M.; Nakano, K. Relationship between IgA Nephropathy and Porphyromonas gingivalis; Red Complex of Periodontopathic Bacterial Species. Int. J. Mol. Sci. 2021, 22, 13022. https://doi.org/10.3390/ijms222313022

AMA Style

Nagasawa Y, Nomura R, Misaki T, Ito S, Naka S, Wato K, Okunaka M, Watabe M, Fushimi K, Tsuzuki K, Matsumoto-Nakano M, Nakano K. Relationship between IgA Nephropathy and Porphyromonas gingivalis; Red Complex of Periodontopathic Bacterial Species. International Journal of Molecular Sciences. 2021; 22(23):13022. https://doi.org/10.3390/ijms222313022

Chicago/Turabian Style

Nagasawa, Yasuyuki, Ryota Nomura, Taro Misaki, Seigo Ito, Shuhei Naka, Kaoruko Wato, Mieko Okunaka, Maiko Watabe, Katsuya Fushimi, Kenzo Tsuzuki, Michiyo Matsumoto-Nakano, and Kazuhiko Nakano. 2021. "Relationship between IgA Nephropathy and Porphyromonas gingivalis; Red Complex of Periodontopathic Bacterial Species" International Journal of Molecular Sciences 22, no. 23: 13022. https://doi.org/10.3390/ijms222313022

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Relationship between IgA Nephropathy and Porphyromonas gingivalis; Red Complex of Periodontopathic Bacterial Species

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