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Beyond HAT Adaptor: TRRAP Liaisons with Sp1-Mediated Transcription

by 1 and 1,2,*
Leibniz Institute on Aging-Fritz Lipmann Institute (FLI), 07745 Jena, Germany
Faculty of Biological Sciences, Friedrich Schiller University Jena, 07743 Jena, Germany
Author to whom correspondence should be addressed.
Academic Editor: Masatoshi Maki
Int. J. Mol. Sci. 2021, 22(22), 12445;
Received: 27 October 2021 / Revised: 9 November 2021 / Accepted: 15 November 2021 / Published: 18 November 2021
(This article belongs to the Special Issue Molecular Mechanisms of Neuronal Death in Neurodegeneration)
The members of the phosphatidylinositol 3-kinase-related kinase (PIKK) family play vital roles in multiple biological processes, including DNA damage response, metabolism, cell growth, mRNA decay, and transcription. TRRAP, as the only member lacking the enzymatic activity in this family, is an adaptor protein for several histone acetyltransferase (HAT) complexes and a scaffold protein for multiple transcription factors. TRRAP has been demonstrated to regulate various cellular functions in cell cycle progression, cell stemness maintenance and differentiation, as well as neural homeostasis. TRRAP is known to be an important orchestrator of many molecular machineries in gene transcription by modulating the activity of some key transcription factors, including E2F1, c-Myc, p53, and recently, Sp1. This review summarizes the biological and biochemical studies on the action mode of TRRAP together with the transcription factors, focusing on how TRRAP-HAT mediates the transactivation of Sp1-governing biological processes, including neurodegeneration. View Full-Text
Keywords: TRRAP; HAT; Sp1; transcription; neuro-development; neuodegeneration TRRAP; HAT; Sp1; transcription; neuro-development; neuodegeneration
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MDPI and ACS Style

Yin, B.-K.; Wang, Z.-Q. Beyond HAT Adaptor: TRRAP Liaisons with Sp1-Mediated Transcription. Int. J. Mol. Sci. 2021, 22, 12445.

AMA Style

Yin B-K, Wang Z-Q. Beyond HAT Adaptor: TRRAP Liaisons with Sp1-Mediated Transcription. International Journal of Molecular Sciences. 2021; 22(22):12445.

Chicago/Turabian Style

Yin, Bo-Kun, and Zhao-Qi Wang. 2021. "Beyond HAT Adaptor: TRRAP Liaisons with Sp1-Mediated Transcription" International Journal of Molecular Sciences 22, no. 22: 12445.

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