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Review

Adipose-Derived Stem/Stromal Cells in Kidney Transplantation: Status Quo and Future Perspectives

1
Plastic and Reconstructive Surgery, Department of Surgical Sciences, Tor Vergata University, 00133 Rome, Italy
2
Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy
3
Kidney Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20135 Milan, Italy
4
Division of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, Switzerland
*
Author to whom correspondence should be addressed.
Gabriele Storti and Evaldo Favi share first authorship.
Academic Editor: Hajime Nagasu
Int. J. Mol. Sci. 2021, 22(20), 11188; https://doi.org/10.3390/ijms222011188
Received: 31 August 2021 / Revised: 11 October 2021 / Accepted: 14 October 2021 / Published: 17 October 2021
(This article belongs to the Special Issue Acute Kidney Injury and Chronic Kidney Diseases)
Kidney transplantation (KT) is the gold standard treatment of end-stage renal disease. Despite progressive advances in organ preservation, surgical technique, intensive care, and immunosuppression, long-term allograft survival has not significantly improved. Among the many peri-operative complications that can jeopardize transplant outcomes, ischemia–reperfusion injury (IRI) deserves special consideration as it is associated with delayed graft function, acute rejection, and premature transplant loss. Over the years, several strategies have been proposed to mitigate the impact of IRI and favor tolerance, with rather disappointing results. There is mounting evidence that adipose stem/stromal cells (ASCs) possess specific characteristics that could help prevent, reduce, or reverse IRI. Immunomodulating and tolerogenic properties have also been suggested, thus leading to the development of ASC-based prophylactic and therapeutic strategies in pre-clinical and clinical models of renal IRI and allograft rejection. ASCs are copious, easy to harvest, and readily expandable in culture. Furthermore, ASCs can secrete extracellular vesicles (EV) which may act as powerful mediators of tissue repair and tolerance. In the present review, we discuss the current knowledge on the mechanisms of action and therapeutic opportunities offered by ASCs and ASC-derived EVs in the KT setting. Most relevant pre-clinical and clinical studies as well as actual limitations and future perspective are highlighted. View Full-Text
Keywords: adipose stem cells; extra-cellular vesicles; kidney transplantation; ischemia–reperfusion injury; tolerance; rejection; acute kidney injury; regenerative medicine adipose stem cells; extra-cellular vesicles; kidney transplantation; ischemia–reperfusion injury; tolerance; rejection; acute kidney injury; regenerative medicine
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MDPI and ACS Style

Storti, G.; Favi, E.; Albanesi, F.; Kim, B.-S.; Cervelli, V. Adipose-Derived Stem/Stromal Cells in Kidney Transplantation: Status Quo and Future Perspectives. Int. J. Mol. Sci. 2021, 22, 11188. https://doi.org/10.3390/ijms222011188

AMA Style

Storti G, Favi E, Albanesi F, Kim B-S, Cervelli V. Adipose-Derived Stem/Stromal Cells in Kidney Transplantation: Status Quo and Future Perspectives. International Journal of Molecular Sciences. 2021; 22(20):11188. https://doi.org/10.3390/ijms222011188

Chicago/Turabian Style

Storti, Gabriele, Evaldo Favi, Francesca Albanesi, Bong-Sung Kim, and Valerio Cervelli. 2021. "Adipose-Derived Stem/Stromal Cells in Kidney Transplantation: Status Quo and Future Perspectives" International Journal of Molecular Sciences 22, no. 20: 11188. https://doi.org/10.3390/ijms222011188

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